MAINTENANCE OF NIAID SPECIFIC PATHOGEN-FREE MACAQUE BREEDING COLONIES

为生物医学研究提供高质量的非人类灵长类动物（NHP）对于实现NIH将基础发现工作转化为临床实践的任务至关重要。这些繁殖群体最初是为了确保NHP移植耐受合作研究小组资助的研究人员能够获得高质量、无特定病原体（SPF）和主要组织相容性型的印度恒河猴和毛里求斯食蟹猴，这是严格研究设计和完成研究目标所必需的。成功的繁殖增加了两个种群的后代总数。随着这些动物的成熟，它们将抵消niaid资助的研究对实验动物的持续需求。2019冠状病毒病大流行和停止从中国进口加剧了现有可用卫生保健产品的短缺，突出了这些菌落作为转化研究中可靠的高质量卫生保健产品国内来源的重要性。该合同将支持负责任的维护和这些SPF菌落的有限扩展，包括定期健康监测、繁殖和富集计划，以及确保及时向调查人员提供研究动物的管理活动。

Provision of quality nonhuman primates (NHP) for biomedical research is critical to achieving the NIH mandate to translate basic discovery work to clinical practice. These breeding colonies were originally established to ensure the NHP Transplantation Tolerance Cooperative Study Group funded investigators have access to the high quality, specific-pathogen-free (SPF), and Major-Histocompatibility typed Indian-origin rhesus and Mauritian cynomolgus macaques necessary for rigorous study design and completion of their study aims. Successful expansion increased total offspring produced by both colonies. As these animal mature, they will offset the ongoing need for research animals for NIAID-funded research. The COVID-19 pandemic and cessation of imports from China have exacerbated pre-existing shortfalls in available NHPs, highlighting the importance of these colonies as a reliable, domestic source of high-quality NHPs for translational research. this contract will support responsible maintenance and limited expansion of these SPF colonies, including regular health monitoring, breeding and enrichment programs, as well as administrative activities that ensure timely provision of research animals to investigators.