MAINTENANCE OF NIAID SPECIFIC PATHOGEN-FREE MACAQUE BREEDING COLONIES

NIAID 无特定病原体猕猴繁殖群的维护

• 批准号: 10932709
• 负责人: GREG WESTERGAARD
• 金额: $ 354.38万
• 依托单位: ALPHA GENESIS INC
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2024-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10932709
• 关键词: Animal Experimentation; Biomedical Research; Breeding; COVID-19 pandemic; Caring; China; Contracts; Ensure; Funding; Health; Histocompatibility; Macaca; Macaca fascicularis; Maintenance; Monitor; National Institute of Allergy and Infectious Disease; Research; Research Design; Research Personnel; Rhesus; Source; Translating; Translational Research; Transplantation Tolerance; United States National Institutes of Health; Work; clinical practice; cooperative study; germ free condition; mature animal; nonhuman primate; offspring; programs

Provision of quality nonhuman primates (NHP) for biomedical research is critical to achieving the NIH mandate to translate basic discovery work to clinical practice. These breeding colonies were originally established to ensure the NHP Transplantation Tolerance Cooperative Study Group funded investigators have access to the high quality, specific-pathogen-free (SPF), and Major-Histocompatibility typed Indian-origin rhesus and Mauritian cynomolgus macaques necessary for rigorous study design and completion of their study aims. Successful expansion increased total offspring produced by both colonies. As these animal mature, they will offset the ongoing need for research animals for NIAID-funded research. The COVID-19 pandemic and cessation of imports from China have exacerbated pre-existing shortfalls in available NHPs, highlighting the importance of these colonies as a reliable, domestic source of high-quality NHPs for translational research. this contract will support responsible maintenance and limited expansion of these SPF colonies, including regular health monitoring, breeding and enrichment programs, as well as administrative activities that ensure timely provision of research animals to investigators.

为生物医学研究提供高质量的非人类灵长类动物(NHP)对于实现NIH将基础发现工作转化为临床实践的任务至关重要。这些繁育群体的建立最初是为了确保NHP移植耐受合作研究小组资助的研究人员能够获得严格研究设计和完成其研究目标所必需的高质量、无特定病原体(SPF)和主要组织相容性类型的印度猕猴和毛里求斯食蟹猴。成功的扩张增加了两个殖民地产生的后代总数。随着这些动物的成熟，它们将抵消NIAID资助的研究对研究动物的持续需求。新冠肺炎大流行和停止从中国进口加剧了先前存在的可用国家卫生政策的短缺，突显了这些群体作为翻译研究用高质量国家卫生政策的可靠国内来源的重要性。这份合同将支持负责任地维护和有限地扩大这些SPF群体，包括定期的健康监测、繁殖和浓缩计划，以及确保及时向调查人员提供研究动物的行政活动。