TO PROVIDE SEQUENCING SERVICES USING WHOLE GENOME SEQUENCING (GERMLINE FFPE) FOR NCI (KLEIN)

为 NCI (KLEIN) 提供使用全基因组测序（种系 FFPE）的测序服务

• 批准号: 10949135
• 负责人: KIM DOHENY
• 金额: $ 77.4万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-27 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10949135
• 关键词: PROVIDE; SEQUENCING; SERVICES; USING; WHOLE

Title: Genetic Predictors of Prostate Cancer Survival in an African American Radical Prostatectomy Cohort: Center for Inherited Disease Research (CIDR) Trans-NIH Collaboration The Center for Inherited Disease Research (CIDR) represents an important collaboration between NCI and NHGRI. Since 1996, Institutes of the NIH have participated in the CIDR contract with the Johns Hopkins University. This trans-NIH collaboration is supported by 10 ICs, with NHGRI serving as the lead IC. CIDR provides to NIH-supported grantees state-of-the-art genomics and statistical genetics services, including whole genome and whole exome sequencing, genome-wide association studies (GWAS) and methylation analysis. In addition to providing outstanding genomics services, CIDR also consults on study design and statistical analysis to NIH grantees. A prime reason for continuing this collaboration is that, as a result of the genomics data provided by CIDR, important new insights into genetic diseases/conditions can potentially move a field of research forward. In addition, the data produced by CIDR is required to be deposited in dbGaP so that the data will be available for further analysis by the scientific community at large. All investigators requesting access through the NIH-funded CIDR Program must submit an electronic application to NIH. X01 applications are continuously accepted and are evaluated for scientific merit by the CIDR Access Committee. The CIDR Board of Governors, which is made up of representatives from the supporting ICs, serves as the second level of review and determines which projects are granted access to the CIDR facility.

标题：非裔美国人根治性前列腺切除术队列中前列腺癌生存率的遗传预测因素： 遗传疾病研究中心（CIDR）跨NIH合作遗传疾病研究中心（CIDR）代表了NCI和NHGRI之间的重要合作。自1996年以来，国家卫生研究院各研究所参加了与约翰霍普金斯大学签订的CIDR合同。这项跨NIH的合作由10个IC支持，NHGRI作为牵头IC。CIDR为NIH支持的受资助者提供最先进的基因组学和统计遗传学服务，包括全基因组和全外显子组测序，全基因组关联研究（GWAS）和甲基化分析。除了提供出色的基因组学服务外，CIDR还为NIH资助者提供研究设计和统计分析方面的咨询。继续这种合作的一个主要原因是，由于CIDR提供的基因组学数据，对遗传疾病/病症的重要新见解可能会推动研究领域的发展。此外，CIDR产生的数据必须存入dbGaP，以便科学界进一步分析。所有要求通过NIH资助的CIDR项目访问的研究者必须向NIH提交电子申请。X 01申请持续被接受，并由CIDR访问委员会评估其科学价值。CIDR理事会由支持性IC的代表组成，是第二级审查机构，决定哪些项目可以使用CIDR设施。