PHARMACOKINETIC AND ORAL BIOAVAILABILITY STUDIES IN RATS

大鼠药代动力学和口服生物利用度研究

• 批准号: 10943488
• 负责人: JAN BEUMER
• 金额: $ 4.5万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-25 至 2024-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10943488
• 关键词: Authorization documentation; Biological Assay; Biological Availability; Blood; Chemical Structure; Chromatography; Collection; Contractor; Contracts; Data; Data Analyses; Dose; Drug Kinetics; Exercise; Formulation; Hemorrhage; High Pressure Liquid Chromatography; Laboratories; Methods; Modeling; Modification; Molecular Weight; Oral; Plasma; Procedures; Property; Protocols documentation; Rattus; Route; Sampling; Solubility; Testing; Time; Validation; Visual; analytical method; anti-cancer; authority; base; cost estimate; design; drug candidate; drug-like compound

The purpose of this task order is to identify suitable formulations for administration of potential drug candidates to rats for early pharmacokinetic studies and to characterize the plasma pharmacokinetics (PK) and bioavailability of anticancer compounds in rats. Chemical structures, molecular weight (MW), and other available properties of test agents will be provided and should be used to provide guidance on formulation approaches (e.g., pH-adjustment, co-solvents). Route and dose level (mg/kg) targets will be provided. There will be a base period and optional tasks included under this task order. The base period will provide for formulation optimization/solubility assessment and one (1) rat pharmacokinetic study with one (1) compound.

这项任务的目的是为大鼠早期药代动力学研究寻找合适的候选药物给药处方，并表征抗癌化合物在大鼠体内的血浆药代动力学(PK)和生物利用度。将提供测试剂的化学结构、相对分子质量(MW)和其他可用的性质，并应用于指导配方方法(例如，pH调节、共溶剂)。将提供路线和剂量水平(mg/kg)目标。 此任务订单下将包括一个基准期和可选任务。基期将用于处方优化/溶解度评估和一(1)种化合物的大鼠药代动力学研究。