REGULATION OF P53 FUNCTION BY SV40 T ANTIGEN

SV40 T 抗原对 P53 功能的调节

基本信息

  • 批准号:
    2008139
  • 负责人:
  • 金额:
    $ 35.81万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1993
  • 资助国家:
    美国
  • 起止时间:
    1993-02-01 至 1997-11-30
  • 项目状态:
    已结题

项目摘要

Alteration of the function of the p53 gene product through mutagenesis causes normal cells to become cancerous. Several viruses, including SV40, encode gene products that bind to p53, presumably to subvert its normal function as a tumor suppressor. Several aims will be pursued in order to study the structure and function of p53 and their regulation by SV40 T antigen. (1) The DNA binding properties of p53 will be investigated in order to understand (i) the DNA sequences to which it binds, (ii) the mode by which it contacts DNA and (iii) the region of the p53 protein that is necessary for binding to DNA. (2) The role of p53 as a transcriptional activator will be investigated. The ability of p53 to regulate transcription alone or in concert with other transcription factors will be examined. (3) The ability of p53 to inhibit DNA replication, by binding to SV40 T antigen or by binding to DNA, will be characterized in vitro and in vivo. (4) The mode by which SV40 T antigen, either alone or when bound to the RB protein, represses the DNA binding and transcriptional activation properties of p53 will be studied. (5) Cellular proteins that bind to and interact functionally with p53 will be identified. (6) The properties and role of Xenopus laevis p53 in oocytes and early embryos will be examined. It is hoped that insight into the functions of viral tumor antigens and cellular tumor suppressors will be gained.
通过诱变改变p53基因产物的功能

项目成果

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会议论文数量(0)
专利数量(0)

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Carol Prives其他文献

Carol Prives的其他文献

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{{ truncateString('Carol Prives', 18)}}的其他基金

Functions and Activities of p53 and Mdm2 in Normal and Cancer Cells
p53 和 Mdm2 在正常细胞和癌细胞中的功能和活性
  • 批准号:
    10437701
  • 财政年份:
    2018
  • 资助金额:
    $ 35.81万
  • 项目类别:
Functions and Activities of p53 and Mdm2 in Normal and Cancer Cells
p53 和 Mdm2 在正常细胞和癌细胞中的功能和活性
  • 批准号:
    9766218
  • 财政年份:
    2018
  • 资助金额:
    $ 35.81万
  • 项目类别:
Functions and Activities of p53 and Mdm2 in Normal and Cancer Cells
p53 和 Mdm2 在正常细胞和癌细胞中的功能和活性
  • 批准号:
    10218070
  • 财政年份:
    2018
  • 资助金额:
    $ 35.81万
  • 项目类别:
Functions and Activities of p53 and Mdm2 in Normal and Cancer Cells
p53 和 Mdm2 在正常细胞和癌细胞中的功能和活性
  • 批准号:
    10657532
  • 财政年份:
    2018
  • 资助金额:
    $ 35.81万
  • 项目类别:
The modulation of PCNA ubiquitination by p21 and its significance for DNA repair
p21对PCNA泛素化的调节及其对DNA修复的意义
  • 批准号:
    7172001
  • 财政年份:
    2006
  • 资助金额:
    $ 35.81万
  • 项目类别:
The modulation of PCNA ubiquitination by p21 and its significance for DNA repair
p21对PCNA泛素化的调节及其对DNA修复的意义
  • 批准号:
    7540975
  • 财政年份:
    2006
  • 资助金额:
    $ 35.81万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    7112862
  • 财政年份:
    2006
  • 资助金额:
    $ 35.81万
  • 项目类别:
Regulation and Interactions of the p53 Family
p53 家族的调控和相互作用
  • 批准号:
    7112854
  • 财政年份:
    2006
  • 资助金额:
    $ 35.81万
  • 项目类别:
The modulation of PCNA ubiquitination by p21 and its significance for DNA repair
p21对PCNA泛素化的调节及其对DNA修复的意义
  • 批准号:
    7325755
  • 财政年份:
    2006
  • 资助金额:
    $ 35.81万
  • 项目类别:
12th International p53 Workshop
第十二届国际p53研讨会
  • 批准号:
    6944062
  • 财政年份:
    2004
  • 资助金额:
    $ 35.81万
  • 项目类别:

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