课题基金 / 基金详情

PAPILLOMAVIRUS DNA REPLICATION--HOST CELL FACTORS

PAPILLOMAVIRUS DNA REPLICATION--HOST CELL FACTORS
乳头瘤病毒 DNA 复制——宿主细胞因素
批准号：
2387261
负责人：
THOMAS MELENDY
金额：
$9.67万
依托单位：
STATE UNIVERSITY OF NEW YORK AT BUFFALO
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-08-01 至 2002-07-31
来源：
https://reporter.nih.gov/project-details/2387261
关键词：
DNA binding protein DNA directed DNA polymerase DNA replication Papillomavirus helicase host organism interaction molecular cloning protein kinase protein purification virus DNA virus infection mechanism

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DESCRIPTION: Papillomaviruses are important human pathogens whose biology is still incompletely understood. This grant is focused on unraveling the repertoire of proteins required for papillomavirus DNA replication in vitro. Reconstituting viral DNA synthesis in vitro has been used before as an invaluable means of understanding the host's replication machinery. Such experiments with SV40 have provided tremendous insight into the basic DNA replication apparatus within mammalian cells. The repertoire of purified proteins sufficient to direct SV40 DNA snthesis in vitro is not sufficient to direct papillomavirus DNA synthesis in vitro. The major goal of this grant is to isolate and characterize the remaining celllular activities required for papillomavirus DNA replication.
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