PRESSURE AND FLOW IN THE RETINAL CIRCULATION

视网膜循环中的压力和流量

• 批准号: 2019834
• 负责人: Matthew Richard Glucksberg
• 金额: $ 14.8万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2019834
• 关键词: blood pressure; blood vessel occlusion; cats; endoscopy; fluorocarbon polymers; hemodynamics; hyperglycemia; intraocular pressure; intravital microscopy; mathematical model; microcirculation; micromanipulator; micropuncture; model design /development; retina circulation; retina disorder

DESCRIPTION (Adapted from applicant's abstract): Disorders of the retinal vasculature are major factors in many retinal diseases, but basic understanding of the control of retinal vascular pressure and the mechanics of blood flow through retinal capillaries is lacking. The applicant proposes to continue use of the servonull micropuncture technique to study the control of microvascular pressure and capillary flow in the retina. Additionally, a new high resolution intravitreal imaging system for visualizing the retinal capillaries will be used. Three lines of study are proposed. In the first line of study, the applicant will complete his basic studies of the control of retinal vascular pressures, and in the second he will begin to examine the factors that control flow at the capillary level. The third line of effort will involve development of a mathematical model of the retinal circulation as a framework for understanding retinal circulation. Conditions to be imposed to study their effects on vascular parameters will include elevated intraocular pressure, isovolemic hemodilution, hyperglycemia, vascular occlusion and other manipulations designed to illuminate fundamental mechanisms and sites of retinal vascular function. Cats are used in these studies because of the comparative similarities of their retina and retinal vasculature to that in humans. The findings are expected to have implications for retinal diseases with circulatory components such as glaucoma, diabetes and retinal occlusive disease.

描述（改编自申请人摘要）：视网膜病变 血管是许多视网膜疾病的主要因素，但基本的 了解视网膜血管压力的控制及其机制 视网膜毛细血管中的血流缺乏。 申请人 建议继续使用servonull显微穿刺技术， 视网膜微血管压力和毛细血管流量的控制。 此外，一种新的高分辨率玻璃体内成像系统， 将使用视网膜毛细血管的可视化。 三条研究路线是 提出了 在学习的第一线，申请人将完成他的基本 研究视网膜血管压力的控制，并在第二次他 将开始检查在毛细管水平上控制流动的因素。 第三条努力路线将涉及开发一个数学模型， 视网膜循环作为理解视网膜 流通 为研究其对血管的影响而施加的条件 参数将包括升高的眼内压、等容性 血液稀释、高血糖、血管闭塞和其他操作 旨在阐明视网膜血管的基本机制和部位 功能 在这些研究中使用猫是因为比较 它们的视网膜和视网膜血管系统与人类的相似之处。 的 研究结果预计将对视网膜疾病产生影响， 青光眼、糖尿病和视网膜阻塞等循环系统疾病 疾病