PRESSURE AND FLOW IN THE RETINAL CIRCULATION

视网膜循环中的压力和流量

• 批准号: 2888407
• 负责人: Matthew Richard Glucksberg
• 金额: $ 15.16万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2888407
• 关键词: blood pressure; blood vessel occlusion; cats; endoscopy; fluorocarbon polymers; hemodynamics; hyperglycemia; intraocular pressure; intravital microscopy; mathematical model; microcirculation; micromanipulator; micropuncture; model design /development; retina circulation; retina disorder

DESCRIPTION (Adapted from applicant's abstract): Disorders of the retinal vasculature are major factors in many retinal diseases, but basic understanding of the control of retinal vascular pressure and the mechanics of blood flow through retinal capillaries is lacking. The applicant proposes to continue use of the servonull micropuncture technique to study the control of microvascular pressure and capillary flow in the retina. Additionally, a new high resolution intravitreal imaging system for visualizing the retinal capillaries will be used. Three lines of study are proposed. In the first line of study, the applicant will complete his basic studies of the control of retinal vascular pressures, and in the second he will begin to examine the factors that control flow at the capillary level. The third line of effort will involve development of a mathematical model of the retinal circulation as a framework for understanding retinal circulation. Conditions to be imposed to study their effects on vascular parameters will include elevated intraocular pressure, isovolemic hemodilution, hyperglycemia, vascular occlusion and other manipulations designed to illuminate fundamental mechanisms and sites of retinal vascular function. Cats are used in these studies because of the comparative similarities of their retina and retinal vasculature to that in humans. The findings are expected to have implications for retinal diseases with circulatory components such as glaucoma, diabetes and retinal occlusive disease.

描述（改编自申请人摘要）：视网膜疾病

项目成果

Phase-slope and group-dispersion calculations in the frequency domain by simple optical low-coherence reflectometry.

通过简单的光学低相干反射计计算频域中的相位斜率和群色散。

• DOI: 10.1364/ao.42.006959
• 发表时间: 2003
• 期刊: Applied optics
• 影响因子: 1.9
• 作者: Kim,YoungL;WalshJr,JosephT;Glucksberg,MatthewR
• 通讯作者: Glucksberg,MatthewR

The influence of elevated intraocular pressure on vascular pressures in the cat retina.

眼压升高对猫视网膜血管压力的影响。

• 发表时间: 1994
• 期刊: Investigative ophthalmology & visual science
• 影响因子: 4.4
• 作者: Attariwala,R;Giebs,CP;Glucksberg,MR
• 通讯作者: Glucksberg,MR

The effect of acute experimental retinal vein occlusion on cat retinal vein pressures.

急性实验性视网膜静脉阻塞对猫视网膜静脉压力的影响。

• 发表时间: 1997
• 期刊: Investigative ophthalmology & visual science.
• 作者: Attariwala,R;Jensen,PS;Glucksberg,MR
• 通讯作者: Glucksberg,MR

Regional variation in capillary hemodynamics in the cat retina.

猫视网膜毛细血管血流动力学的区域差异。

• 发表时间: 1998
• 期刊: Investigative ophthalmology & visual science.
• 作者: Jensen,PS;Glucksberg,MR
• 通讯作者: Glucksberg,MR

Enhanced oxygen delivery induced by perfluorocarbon emulsions in capillary tube oxygenators.

毛细管充氧器中的全氟化碳乳液增强了氧气输送。

• DOI: 10.1097/00002480-199407000-00077
• 发表时间: 1994
• 期刊: ASAIO journal (American Society for Artificial Internal Organs : 1992)
• 作者: Vaslef,SN;Goldstick,TK
• 通讯作者: Goldstick,TK