DEVELOPMENTAL IMMUNOLOGY RESEARCH
发育免疫学研究
基本信息
- 批准号:6099693
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1996
- 资助国家:美国
- 起止时间:1996-09-01 至 1998-08-31
- 项目状态:已结题
- 来源:
- 关键词:AIDS African American HIV envelope protein gp120 HIV infections antibody formation antibody receptor cell mediated cytotoxicity complement cytokine cytokine receptors enzyme linked immunosorbent assay female flow cytometry helper T lymphocyte human subject immune system immunoglobulin A immunoglobulin G immunoglobulin M immunologic memory immunoregulation lymphocyte proliferation phagocytes
项目摘要
The primary objective of component C of RFA-NIH-92-AI-14 is to "provide
investigators with resources to answer clinically relevant questions with
emphasis on utilizing specimens generated from ACTG protocols". The
present proposal will address this objective by providing human and
logistic resources for the evaluation of immune functions in patients
enrolled in AIDS clinical trials at Meharry Medical College.
HIV compromises the immune system in two major ways: Severe depletion
of CD4+ T-cells and decline in T-helper (th) cell functions. CD4+ cell
counts are the most commonly used immunological parameter for the
evaluation of patients with HIV/AIDS. However, the loss of Th cell
functions precedes and is independent of the decline in CD4+ cell counts.
Since there is a connection between the impairment of Th cell functions
and the clinical evolution of HIV/AIDS, we propose the early
characterization and evaluation of specific and non-specific immune
responses as necessary tools for diagnosis and for monitoring medical
intervention in HIV/AIDS. The objective of this component is the
strengthen our existing human and laboratory resources to provide support
for research in immunology of AIDS and to develop and provide less
commonly used research tools to look at functional immune parameters in
human subjects involved in ACTU protocols at Meharry. These functional
parameters are: 1) Specific immune functions (memory responses). a)
cellular immunity: lymphocyte responses to recall antigens (i.e. HIV
antigens and mitogens), capacity of human cytotoxic lymphocytes to kill
target cells expressing or carrying HIV antigens, b) antibody responses:
human production of specific antibody isotypes against HIV antigens, or
other relevant antigens, and evaluation of T-helper activity in the
specific antibody response to Tetanus toxoid in vivo. 2) Non-specific
immune responses. a) phagocytic cell function: study of the metabolic
activity of phagocytic cells by chemiluminescence, b) lymphocyte
activation: flowcytometry analyses of the expression and distribution
of lymphocyte markers for activation and identification of lymphocyte
subsets associated with the progression of HIV infection/AIDS, c) Humoral
parameters for cellular and humoral immune functions: quantitation of
cytokines (i.e. IL-1 alpha and beta, IL-2, IL-4, IL-6, TNF alpha and
beta, gammaIFN), complement fractions, neopterin, beta2-microglobulin and
others which may become relevant in HIV infection.
RFA-NIH-92-AI-14组件C的主要目标是
拥有回答临床相关问题的资源的研究人员
强调利用ACTG议定书产生的标本“。
目前的提案将通过提供人力和人力资源来实现这一目标
评估患者免疫功能的后勤资源
在梅哈里医学院参加艾滋病临床试验。
HIV主要通过两种方式损害免疫系统:严重衰竭
CD4+T细胞减少,T辅助(TH)细胞功能下降。CD4+细胞
计数是最常用的免疫学参数
对艾滋病毒/艾滋病患者的评估。然而,Th细胞的丧失
功能先于并独立于CD4+细胞数量的下降。
由于Th细胞功能受损之间存在联系
以及HIV/AIDS的临床演变,我们建议及早
特异性免疫和非特异性免疫的特性和评价
作为诊断和监测医疗的必要工具的答复
对艾滋病毒/艾滋病的干预。此组件的目标是
加强我们现有的人力和实验室资源以提供支持
用于艾滋病免疫学的研究,并开发和提供更少的
常用的研究工具来查看功能免疫参数
在梅哈里参与ACTU方案的人类受试者。这些功能
参数包括:1)特定的免疫功能(记忆反应)。a)
细胞免疫:淋巴细胞对召回抗原(如艾滋病毒)的反应
抗原和有丝分裂原),人细胞毒淋巴细胞的杀伤能力
表达或携带HIV抗原的靶细胞,b)抗体反应:
人类产生针对HIV抗原的特定抗体同种类型,或
其他相关抗原,以及T辅助细胞活性的评估
体内对破伤风类毒素的特异性抗体反应。2)非特定
免疫反应。A)吞噬细胞功能:代谢研究
化学发光法测定吞噬细胞活性,b)淋巴细胞
活化:流式细胞术分析细胞的表达和分布
淋巴细胞活化和鉴定的淋巴细胞标志物
与艾滋病毒感染/艾滋病进展有关的子集,c)体液
细胞和体液免疫功能的参数:量化
细胞因子(即IL-1α和β、IL-2、IL-4、IL-6、肿瘤坏死因子α和
β-干扰素)、补体组分、新喋呤、β-2-微球蛋白和
其他可能与艾滋病毒感染相关的因素。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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