Project: Survivorship Care Physical Activity Initiative to Improve Disparities in HRQoL for Prostate Cancer Survivors (RELate Study)

完整研究项目1：减少HRQOL差异的生存护理体力活动计划 前列腺癌幸存者(相关研究) 摘要 前列腺癌(PCA)治疗的晚期效应可导致独特的身体和心理社会问题， 影响他们长期的健康相关生活质量(HRQOL)。增加体力活动(PA)是一种可修改的 可能针对与PCa生存相关的治疗结果和生活方式的风险因素 行为。PA的增加可能对非洲血统(AA)PCA幸存者的预后产生最大影响 倾向于较低的HRQOL和总体存活率，以及缺乏锻炼、饮食不佳和 肥胖率是最普遍的。众所周知，运动可以改善癌症患者的预后 幸存者们对PA可能改善的生物行为机制和途径知之甚少 HRQOL和提高总体存活率。晚期糖基化终末产物(Ags)是一种反应性代谢产物。 在正常新陈代谢和生物大分子氧化过程中产生。生活方式因素 例如久坐不动的生活方式、糟糕的饮食和肥胖会增加身体的年龄水平。调查人员 假设在先前对前列腺癌幸存者进行的人类PA/饮食干预的随机试验中 诊断为I-III期PCA(n=120)，较低的年龄水平将与改善的HRQOL相关，并将导致 AA和欧美(EA)试验参与者之间免疫反应的差异变化。这个 研究人员进一步假设，在老鼠模型干预中，生活方式的机械性含义-- 肿瘤相关免疫反应和肿瘤生长和/或进展的相关年龄将模拟这些 在人体模型中发现。目标1是完成为期1年的2组ARM(干预与常规护理)的随机试验 PA/饮食干预对确诊为I-III期PCA的男性(由M.Ahmed博士、SCSU和D博士共同领导) 特纳，MUSC-HCC)。目的2是评估生活方式干预对PA和饮食的影响，并确定其 在被诊断为I-III期PCa的男性中，与年龄、年龄先兆和HRQOL的关系(由Dr。 艾哈迈德，南加州大学)。目标3是使用自发的PCA生活方式小鼠模型来定义年龄-愤怒的作用 免疫细胞表型和肿瘤进展的信号(由MUSC-HCC的特纳博士领导)。结果是 可能导致对药理学和生活方式调整的创新见解，并可能确定具有保护作用的 观察到AA和EA患者在PCA治疗结果上的差异的可能因素。这 项目与本申请中包括的其他研究项目具有协同关系

Full Research Project 1: Survivorship Care Physical Activity Initiative to Reduce Disparities in HRQOL for Prostate Cancer Survivors (RELate Study) SUMMARY The late effects of prostate cancer (PCa) treatment can lead to unique physical and psychosocial issues that impact their long-term health-related quality of life (HRQOL). Increased physical activity (PA) is a modifiable risk factor which may be targeted to address PCa survivorship-related treatment outcomes and lifestyle behaviors. Increased PA may have greatest impact on outcomes for African-ancestry (AA) PCa survivors, who tend to have lower HRQOL and overall survival, and in whom factors such as a lack of exercise, poor diet, and rates of obesity are most prevalent. While it is well-known that exercise can improve prognosis among cancer survivors, little is known about the bio-behavioral mechanisms and pathways through which PA may improve HRQOL and increase overall survival. Advanced glycation endproducts (AGEs) are reactive metabolites produced during normal metabolism as well as the oxidation of biological macromolecules. Lifestyle factors such as a sedentary lifestyle, poor diet, and obesity increase AGE levels in the body. The investigators hypothesize that in a randomized trial of a human PA/dietary intervention with PCa survivors previously diagnosed with Stage I-III PCa (n=120), lower AGE levels will correlate with improved HRQOL, and will lead to differential changes in immune response between AA and European American (EA) trial participants. The investigators further hypothesize that in a mouse model intervention, the mechanistic implications of lifestyle- associated AGEs to tumor-associated immune response and tumor growth and/or progression will mimic those found in human models. Aim 1 is to complete a 1-year, 2-arm (intervention vs usual care) randomized PA/dietary intervention in men diagnosed with stage I-III PCa (co-led by Dr. M. Ahmed, SCSU and Dr. D. Turner, MUSC-HCC). Aim 2 is to evaluate the effect of lifestyle intervention on PA and diet, and define their relationship with AGEs, AGEs pre-cursors, and HRQOL in men diagnosed with stage I-III PCa (led by Dr. Ahmed, SCSU). Aim 3 is to use a spontaneous PCa lifestyle mouse model to define the role of AGE-RAGE signaling to immune-cell phenotypes and tumor progression (led by Dr. Turner, MUSC-HCC). The results could lead to innovative insights for pharmacologic and lifestyle adjustment, and could identify protective factors that may underlie observed differences in PCa treatment outcomes between AA and EA men. This project is synergistically related to the other research projects included in this application