Heading and Soccer: understanding cognitive risks, benefits, and the potentialmediating role of white matter

头球和足球：了解认知风险、益处以及白质的潜在中介作用

基本信息

批准号：
10909633
负责人：
Michael Lawrence Lipton
金额：
$ 70.97万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10909633
关键词：
Adult Adverse effects Aerobic Age Alleles American Anisotropy Attenuated Benefits and Risks Brain Brain Concussion Brain Injuries Brain-Derived Neurotrophic Factor Cognitive Diffusion Diffusion Magnetic Resonance Imaging Enrollment Equilibrium Exhibits Exposure to Follow-Up Studies Foundations Future Goals Harm Reduction Health Healthcare Impairment Joints Knowledge Longitudinal Studies Magnetic Resonance Imaging Measures Mediating Mediation Mediator Morbidity - disease rate Myelin Myelin Water Imaging Nerve Degeneration Outcome Participant Personal Satisfaction Persons Physical activity Planet Earth Play Productivity Reporting Risk Role Sampling Soccer Sports Structure Testing Time VO2max Water Work apolipoprotein E-4 attenuation brain health central nervous system injury cognitive change cognitive enhancement cognitive function cognitive performance cognitive testing combat genetic variant head impact improved indexing injury and repair insight myelination neuroimaging protective effect public health relevance risk perception subconcussion white matter white matter change young adult

项目摘要

PROJECT SUMMARY/ABSTRACT A key goal of “Healthy People 2030” is to improve the health of adults through aerobic physical activity. Soccer, the most popular sport on earth, is an aerobic outlet for more than 25 million Americans. The potential benefits of soccer are offset by repetitive subconcussive head impacts (RSHI) from soccer heading. RSHI are associated with exposure-dependent adverse effects on neuroimaging and on cognitive performance, independent of collisions and concussion. The tradeoffs between aerobic benefits and RSHI-related harms are not known. The central aim of this proposal is to examine the aerobic benefits of soccer play, in relation to RSHI harms, for brain structure and function, and to explore person-level factors that modify this risk-benefit tradeoff. Beneficial effects of aerobic capacity and adverse subclinical effects of RSHI can be detected with neuroimaging of white matter. However, little is known about their joint impact on white matter and, in turn, how white matter features mediate effects on cognitive function. Fundamental knowledge on the RSHI risk-benefit balance can inform our understanding of RSHI morbidity and its mitigation beyond the specific context of soccer, such as other sports and combat. Prior work on RSHI effects has not specifically measured aerobic capacity, and little is known about whether and how white matter mediates exposure-outcome associations. Our proposed 2-year longitudinal follow up study of 280 young adults, including soccer players with high (n=70) and low (n=70) exposure to RSHI, non-collision athletes (n=70) and non-athlete controls (n=70), will test the hypothesis that aerobic capacity-engendered benefits confound and modify the adverse effects of RSHI on white matter that, in turn, is a mediator of adverse cognitive effects. We will measure aerobic capacity (VO2max) and RSHI over 2 years and perform Myelin Water and Microstructure MRI of white matter as well as cognitive assessments, at enrollment and 2 years later. We will address the following specific aims: Aim 1: Evaluate the joint effects of VO2max and RSHI on white matter myelination and microstructure. Aim 2: Assess mediation by white matter of the known associations of VO2max and RSHI with cognitive performance. Aim 3: Explore the BDNF-Val66met and ApoE-ε4 gene variants as modifiers of the tradeoff of VO2max and RHSI-mediated effects on white matter. Delineating risk vs. benefit to cognitive performance from soccer can transform perception of risk by stakeholders, facilitate choice and guidance on soccer participation and heading. Choices that impact young adult players, with high RSHI exposure and decades of future needs, have the potential to impact their wellbeing, healthcare footprint and productivity for decades.

项目摘要/摘要 “健康人2030”的关键目标是通过有氧运动来改善成年人的健康。足球，地球上最受欢迎的运动是超过2500万美国人的有氧运动。潜在的好处足球被足球标题重复的亚语头部影响（RSHI）所抵消。 RSHI是关联的对神经影像学和认知表现的暴露依赖性不利影响，与碰撞和脑震荡。有氧福利与RSHI相关危害之间的权衡尚不清楚。该提案的核心目的是检查足球比赛的有氧好处，与RSHI Harms有关用于大脑的结构和功能，并探索改变这种风险效果权衡的人级因素。可以通过神经成像检测有氧能力和不良亚临床效应的有益影响白质。但是，他们对白质的共同影响知之甚少，而白质有多白质具有介导对认知功能的影响。关于RSHI风险效益平衡的基本知识可以告知我们对RSHI发病率及其缓解足球特定背景的理解，例如其他运动和战斗。关于RSHI效应的先前工作尚未具体测量有氧运动能力，很少知道白质是否以及如何介导暴露结果关联。我们提议的2年 280名年轻人的纵向后续研究，包括高（n = 70）和低（n = 70）的足球运动员接触RSHI，非碰撞运动员（n = 70）和非运动员对照（n = 70），将检验以下假设。有氧能力启动的好处混淆并修改了RSHI对白质的不利影响反过来，这是对认知影响不利的中介者。我们将测量有氧运动能力（VO2MAX）和 RSHI超过2年，并执行白质和认知的髓水和微结构MRI 评估，注册和两年后。我们将解决以下具体目标：目标1：评估 Vo2max和RSHI对白质髓鞘和微观结构的关节作用。目标2：评估调解 Vo2max和RSHI与认知表现的已知关联的白色物质。目标3：探索 BDNF-VAL66MET和APOE-ε4基因变体作为VO2MAX和RHSI介导的效果的修饰符关于白质。从足球中划定风险与对认知表现的好处可以改变对利益相关者的风险，促进足球参与和标题的选择和指导。影响的选择年轻的成年球员，RSHI敞口高，未来数十年的需求，有可能影响他们的数十年来的福祉，医疗保健足迹和生产力。