PRE-CLINICAL AND CLINICAL MULTIPURPOSE PREVENTION TECHNOLOGIES

NICHD支持广泛的避孕研究，包括开发男性避孕药具和多用途预防技术的努力。 预防怀孕和性传播感染（STI）的MPT产品将增加女性和男性的性健康和生殖健康选择。 MPT由多种药物组合组成，可用于预防妊娠、性传播感染和/或艾滋病毒，使用按需和事件驱动或长效药物输送系统（DDS）输送，具有流变学/生物物理特性和产品用户感知（外观、感觉、有效性、安全性和作用持续时间），支持用户接受（首次使用、后续使用和习惯使用）。通过结合预防怀孕和艾滋病毒或性传播感染的产品，MPT可能比单独的产品有更大的吸收和坚持。MPT概念的关键是创建DDS以支持使用便利性，不仅安全且持续递送药物，而且具有与用户需求相关的作用持续时间。MPT（避孕药和非避孕药）可能包括广泛的分娩持续时间和使用模式，从按需、事件驱动或持续/延长释放持续时间（数月至数年）。

NICHD supports a broad range of contraceptive research, including efforts to develop male contraceptives and Multipurpose Prevention Technologies (MPTs). MPT products that prevent both pregnancy and sexually transmitted infections (STIs) would increase sexual and reproductive health options for both women and men. MPTs are composed of a combination of drugs that can target prevention of pregnancy, STIs and/or HIV, delivered using either an on-demand and event-driven or long-acting drug delivery system (DDS) with rheological/biophysical properties and product user perceptions (look, feel, effectiveness, safety and duration of action) that support user uptake (first use, subsequent use and habitual use). By combining prevention products for pregnancy and HIV or STI, the MPT may have a greater uptake and adherence than individual products. Key to the concept of MPTs is creation of DDS to support convenience of use, that not only are safe and deliver the drugs consistently but have durations of action relevant to the user needs. MPTs (contraceptive and non-contraceptive) may encompass a wide range of delivery durations and use patterns from on demand, event-driven or sustained/extended-release durations (months to years).