Development and Divergence of Whole-Brain Activity
全脑活动的发展和分化
基本信息
- 批准号:10617391
- 负责人:
- 金额:$ 47.34万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-05-05 至 2027-03-31
- 项目状态:未结题
- 来源:
- 关键词:AdultAffectAgeAnimal BehaviorAnimalsBehaviorBiological ModelsBrainBrain imagingCaenorhabditis elegansCalciumCellsChemicalsCollectionComplementCuesDevelopmentFundingGene ExpressionGeneticGoalsHousingHumanImageIndividualLarvaLearningMapsMeasurementMeasuresMicrofluidic MicrochipsMicrofluidicsModelingMoltingMotor NeuronsNational Institute of Neurological Disorders and StrokeNeuronsNewborn InfantOpticsOutputPatternProcessResolutionSensorySeriesStimulusStructureSynapsesSystemTechniquesTouch sensationWorkbehavior predictioncell typecomputerized toolsconnectomeexpectationhatchingindividual variationinsightinter-individual variationlithographynutritionreproductiveresponsetoolyoung adult
项目摘要
Project Summary/Abstract
An animal’s brain consists of interconnected neurons that are responsible for processing sensory information over
many timescales to guide behavior. The function of that brain is determined partially by the animal’s connectome
– the topology, strength, and valence of every connection in its brain. While a draft of the whole connectome for
an animal (the worm Caenorhabditis elegans) has been available for decades, recent work has found that this
connectome varies dramatically through development and between individuals. It is not stereotyped as expected.
We do not know how this large variability in connectivity manifests itself in brain activity through development
or between individuals. Nonetheless, the single connectome an animal has must somehow be able to support
every behavior that the animal may perform in a given instant. Each of these behaviors may engage overlapping
portions of the brain.
This project aims to leverage calcium imaging to study how whole-brain activity in C. elegans varies through
development and between individuals. Our goal is to clarify precisely how large-scale structure and function
are related in a simple system. To do this, we will perform whole-brain imaging with cellular resolution in a
collection of behaving individual animals as they progress from newly-hatched larvae through a series of molts
and turn into adults. These long-term calcium recordings will be complemented by microfluidic measurements
of whole-brain responses to chemosensory cues at multiple developmental stages. Throughout this process, we
will focus on the following big questions: (1) How does the activity of every neuron in a worm change through
development? (2) How does brain activity vary between genetically identical individuals? (3) How are each of
the above questions affected by changes in environmental context? (4) How does the relationship between brain
activity and connectivity change over development, and how does it vary between individuals?
If successful, this work could provide unprecedented insight into how brain function changes as an animal
adds neurons, connections, and synapses. It will show how inter-individual and intra-individual variation are
related to the brain’s connectome. This will have immediate value in guiding expectations about how brain activity
and brain wiring are related in other model systems and humans, where direct information about wiring is less
readily available.
项目概要/摘要
动物的大脑由相互连接的神经元组成,负责处理感觉信息
许多时间尺度来指导行为。大脑的功能部分由动物的连接组决定
– 大脑中每个连接的拓扑结构、强度和效价。虽然整个连接组的草稿
一种动物(秀丽隐杆线虫)已经存在了几十年,最近的研究发现,这种
连接组在发育过程中以及个体之间存在显着差异。它并不像预期的那样刻板。
我们不知道连接性的这种巨大变化如何在发育过程中的大脑活动中体现出来
或个人之间。尽管如此,动物所拥有的单一连接组必须能够以某种方式支持
动物在给定时刻可能执行的每一种行为。这些行为中的每一个都可能涉及重叠
大脑的部分。
该项目旨在利用钙成像来研究秀丽隐杆线虫的全脑活动如何变化
发展和个体之间。我们的目标是准确阐明大规模结构和功能如何
在一个简单的系统中相关。为此,我们将在
行为个体动物的集合,它们从新孵化的幼虫经过一系列蜕皮过程
并变成大人。这些长期钙记录将得到微流体测量的补充
多个发育阶段的全脑对化学感应线索的反应。在整个过程中,我们
将重点研究以下大问题:(1)蠕虫中每个神经元的活动如何通过
发展? (2) 基因相同的个体之间的大脑活动有何不同? (3) 各自的情况如何
上述问题受环境背景变化影响吗? (4) 与大脑的关系如何
活动和连通性随着发展而变化,个体之间有何变化?
如果成功,这项工作可以为动物大脑功能如何变化提供前所未有的见解
添加神经元、连接和突触。它将显示个体间和个体内的差异如何
与大脑的连接组有关。这对于指导人们对大脑活动如何进行预期具有直接价值
和大脑接线在其他模型系统和人类中是相关的,其中有关接线的直接信息较少
随时可用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Vivek Venkatachalam其他文献
Vivek Venkatachalam的其他文献
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{{ truncateString('Vivek Venkatachalam', 18)}}的其他基金
Development and Divergence of Whole-Brain Activity
全脑活动的发展和分化
- 批准号:
10417604 - 财政年份:2022
- 资助金额:
$ 47.34万 - 项目类别:
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