Leveraging existing HIV differentiated service delivery models to screen and treat hypertension in Ugandan persons living with HIV for dual control

利用现有的艾滋病毒差异化服务提供模式对乌干达艾滋病毒感染者进行高血压筛查和治疗，实现双重控制

• 批准号: 10625472
• 负责人: Martin Muddu
• 金额: $ 11.34万
• 依托单位: INFECTIOUS DISEASES RES COLLABORATION
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10625472
• 关键词: Address; Adoption; Adult; Affect; Antihypertensive Agents; Area; Award; Blood Pressure Monitors; Cardiovascular Diseases; Caring; Client; Clinic; Clinical; Clinical Medicine; Collaborations; Communities; Community Healthcare; Consolidated Framework for Implementation Research; Control Groups; Data; Effectiveness; End stage renal failure; Environment; Focus Groups; Funding; Goals; Grant; Guidelines; HIV; Health Personnel; Health system; High Prevalence; Hypertension; Infectious Diseases Research; Interruption; Intervention; Interview; Leadership; Manuscripts; Medicine; Mentors; Methods; Modeling; Myocardial Infarction; Observational Study; Patients; Persons; Pharmaceutical Preparations; Population Attributable Risks; Prevalence; Productivity; Protocols documentation; Qualitative Research; Quasi-experiment; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Recommendation; Research; Research Methodology; Research Personnel; Research Training; Risk Factors; Rural; Scientist; Series; Service delivery model; Services; Social support; Structure; Taxonomy; Time; Training; Treatment Protocols; Uganda; Workload; World Health Organization; Writing; career; community center; design; drug distribution; effectiveness evaluation; evidence base; experimental study; group intervention; hypertension control; hypertension treatment; implementation design; implementation evaluation; implementation research; implementation science; implementation strategy; improved; innovation; mobile application; mobile computing; mortality; patient oriented; primary outcome; programs; scale up; screening; service delivery; service providers; skills; treatment guidelines

PROJECT SUMMARY/ABSTRACT The overall goal of the proposed Emerging Global Leader Award is to support Dr. Martin Muddu’s research training to develop as an independent implementation science investigator in HIV and hypertension. Dr. Muddu is a research scientist at the Infectious Diseases Research Collaboration (IDRC) in Kampala, Uganda. He proposes to conduct an implementation science study to integrate HTN screening and treatment into community-based, patient-centered models of HIV care known as “differentiated service delivery.” Accomplishing the proposed study in this application will facilitate his training goals to: 1) gain mastery of mixed methods implementation science research; 2) acquire expertise in design and analysis of quasi- experimental studies; and 3) develop skills in leadership, grant and manuscript writing, and mentoring of junior investigators. This proposal builds on the skills he already has in HIV and hypertension clinical medicine and methods of observational studies. He will leverage an interdisciplinary team of mentors and advisors with expertise in his area of study to become a productive independent researcher. Hypertension affects nearly one-third of Ugandan PLHIV, a large proportion of whom are undiagnosed and untreated. The World Health Organization HEARTS package is an evidence-based strategy for HTN management, which we propose to adapt, integrate, and implement into community HIV differentiated service delivery models using rigorous implementation science methods. This will form the integrated hypertension-HIV differentiated service delivery model. We will then evaluate the implementation and effectiveness of the integrated hypertension-HIV differentiated service delivery model regarding hypertension control in PLHIV. If implemented, this project will generate evidence to inform guidelines for integration of HTN management into patient centered community models of HIV care in Uganda and beyond.

项目概要/摘要 拟议的新兴全球领袖奖的总体目标是支持 Martin Muddu 博士的研究 培训成为艾滋病毒和高血压领域的独立实施科学研究者。穆杜博士 是乌干达坎帕拉传染病研究合作组织 (IDRC) 的研究科学家。他 提议开展一项实施科学研究，将高血压筛查和治疗纳入 以社区为基础、以患者为中心的艾滋病毒护理模式，称为“差异化服务提供”。 完成本应用程序中提出的研究将有助于他的培训目标：1）掌握 混合方法实施科学研究； 2）获得准设计和分析的专业知识 实验研究； 3) 培养领导能力、资助和稿件写作以及对初级学生的指导技能 调查人员。该提案建立在他在艾滋病毒和高血压临床医学方面已有的技能和 观察研究的方法。他将利用一支由导师和顾问组成的跨学科团队 其研究领域的专业知识成为一名富有成效的独立研究员。高血压几乎影响 乌干达三分之一的艾滋病毒感染者，其中很大一部分未经诊断和治疗。世界卫生 组织 HEARTS 包是一种基于证据的 HTN 管理策略，我们建议 使用严格的方法调整、整合和实施社区艾滋病毒差异化服务提供模式 实施科学方法。这将形成一体化的高血压-艾滋病毒差异化服务提供 模型。然后我们将评估高血压-艾滋病毒综合治疗的实施和有效性 艾滋病毒携带者高血压控制的差异化服务提供模式。如果实施，该项目将 生成证据，为将高血压管理纳入以患者为中心的社区提供指导方针 乌干达及其他地区的艾滋病毒护理模式。