Core C: Neuroimaging Core

额颞退行性变(FTD)是一种进行性疾病，其特征是病理和 以额叶和颞叶为主的解剖分布的神经退行性变。然而，有广泛的 FTD患者疾病分布的异质性，包括几种临床表型，几种 疾病的潜在病理来源，以及基因贡献的不同来源。多式联运 神经成像，包括结构磁共振成像(SMRI)和扩散磁共振成像(DMRI)，提供了一种重要的工具 刻画FTD在个体中的异质性和分布的基因座，以便客观地改善 FTLD-tau和FTLD-TDP之间的诊断鉴别，将这些病理与表型联系起来，以及 告知这些复杂网络障碍的生物学机制。功能灌注磁共振成像(PMRI)和 静息状态BOLD功能磁共振成像(RsfMRI)方法通过提供更多独特的见解来增强sMRI和dMRI 早期疾病和纵向发展的起源、比率和模式。7T MRI提供了独特的 有机会更好地了解FTLD-TDP与FTLD-Tau的微观机制。 因此，成像核心C的总体目标是提供必要的基础设施来支持最先进的技术 本研究项目I-V中3T和7T MRI采集及神经影像数据的网络分析 程序。该核心还将与核心B-E紧密结合，以促进我们的跨学科和 融合体内和体外的方法，以提高我们对FTD作为一种网络障碍的理解。在……里面 具体地说，我们将生成反映FTD大脑的MRI派生结构属性的图形“节点”和图形 “边”反映结构和/或功能的连接性，以促进网络神经科学方法 每个单独的项目。为了实现这一目标，我们提出了三个具体目标：(1)收集体内最先进的信息 FTD患者的3T MRI多模式神经成像数据，包括sMRI、dMRI、pMRI和rsfMRI；(2)提供 标准操作规程(SOP)的横截面和纵向图像处理流水线 神经成像测量；以及(3)开发新的7特斯拉(7T)收购策略，以获得超高 分辨率(&lt；0.3mm3)数据和测试生物驱动的假设。

Frontotemporal degeneration (FTD) is a progressive disorder characterized by pathology and neurodegeneration in a predominantly frontal and temporal anatomic distribution. However, there is extensive heterogeneity of disease distribution across individuals with FTD, including several clinical phenotypes, several underlying pathological sources of disease, and distinct sources of genetic contributions. Multimodal neuroimaging, including structural MRI (sMRI) and diffusion MRI (dMRI), provides an important tool to characterize the heterogeneous and distributed loci of FTD in individuals in order to objectively improve the diagnostic discrimination between FTLD-tau and FTLD-TDP, relate these pathologies to phenotypes, and inform the biological mechanisms of these complex network disorders. Functional perfusion MRI (pMRI) and resting state BOLD fMRI (rsfMRI) approaches enhance sMRI and dMRI by providing additional unique insights into the origin, rate, and pattern of early disease and longitudinal progression. 7T MRI provides a unique opportunity to better understand the microstructural mechanisms that distinguish FTLD-TDP from FTLD-Tau. Thus, the overall goal of Imaging Core C is to provide the necessary infrastructure to support state-of-the-art 3T and 7T MRI acquisition and network analyses of neuroimaging data in Projects I-V of this research program. This Core will also be closely integrated with Cores B-E to facilitate our interdisciplinary and convergent in vivo and ex vivo approach to improving our understanding of FTD as a network disorder. In particular, we will generate graph “nodes” reflecting MRI-derived structural properties of FTD brains and graph “edges” reflecting structural and/or functional connectivity to facilitate the network neuroscience approach of each individual project. To accomplish this goal we propose 3 Specific Aims: (1) Collect state-of-the-art in vivo 3T MRI multimodal neuroimaging data in FTD patients including sMRI, dMRI, pMRI, and rsfMRI; (2) Provide a cross-sectional and longitudinal image processing pipeline for standard operating procedure (SOP) neuroimaging measurements; and (3) Develop novel 7 Tesla (7T) acquisition strategies to yield ultra-high- resolution (<0.3mm3) data and test biologically-motivated hypotheses.