权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

"Plasma and cellular immune biomarkers of Kaposi's sarcoma in HIV-1 suppressed patients"

“HIV-1 抑制患者中卡波西肉瘤的血浆和细胞免疫生物标志物”

基本信息

批准号：
10871931
负责人：
Salum Juma Lidenge
金额：
$ 10万
依托单位：
MUHIMBILI UNIVERSITY/ ALLIED HLTH SCIS
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10871931
关键词：
Acceleration Acquired Immunodeficiency Syndrome Address Africa Africa South of the Sahara Age Age Years Aging Area Attention Biological Markers Biometry Cancer Patient Caring Cessation of life Child Chronic Chronology Clinical Clinical Research Coupled Data Data Analyses Data Set Development Diagnosis Disease Educational workshop Elderly Electronics Ethics Female Fostering Future Gender Generations Grant HIV HIV Infections HIV Seropositivity HIV-1 HIV/AIDS Health Immunologic Markers Incidence Inequality Inflammation Infrastructure Instruction Interdisciplinary Study Kaposi Sarcoma Life Expectancy Longevity Malignant Neoplasms Manuscripts Mentors Mothers Nature Oceans Outcome Output Parents Patient Care Patients Persons Plasma Population Preparation Prevalence Process Productivity Professional Competence Research Research Design Research Personnel Research Priority Research Training Sample Size Tanzania Time Training United States National Institutes of Health age related aging population antiretroviral therapy cancer diagnosis career co-infection cohort comorbidity data curation demographics design disorder control diversity and inclusion hands on research improved mortality pandemic disease recruit response scale up skill acquisition skills sociodemographics tool training opportunity trend

项目摘要

PROJECT SUMMARY/ABSTRACT Successful ART coverage has has reduced AIDS-related mortality from 2.2 million in mid 2000s to 1.8 million in 2019. In turn, this has led to global increase in life expectancy of PLWH. In the US, it is estimated that 50% of the PLWH are older than 50 years and accounts for 70% of total deaths among PLWH. The ageing population of PLWH is now facing an increase in age-related non-communicable diseases like cancers. However, in sub-Saharan Africa (SSA) where ~66% of global 38.4 million PLWH reside, data on the changing demographics of the HIV pandemic are scarce. Although it is expected that non-HIV- associated malignancies (HIVAM) to increase and at an earlier age at diagnosis as a consequence of ageing among PLWH, there is limited data on the impact of HIV and ageing on cancer development in SSA. The limited data on the impact of ageing on health and the nature of the accelerated ageing process in PLWH in SSA could be partly due to the fact that, 1) prior to ART scale up in Africa, most PLWH were not treated with ART and died at an earlier age, rarely lived beyond 50 years of age. It is only through ART a new generation of PLWH are now ageing in SSA. 2) Importantly, in the past, most of the training opportunities in SSA focused on the training of clinicians to address patient care with minimal emphasis on research training. Coupled with limited research training opportunities, particularly in HIV and ageing, this has led to low research output in SSA. To address this gap of well-trained HIV researchers, we are proposing to recruit and mentor an early-stage female investigator (Dr. Herrieth) on the basics of HIV research through academic instruction and conducting a hands-on research training to determine the incidence, trends, and outcome of non-HIVAM in ageing PLWH in Tanzania. The overall objective is to train the already identified young, enthusiastic female early-stage investigator on expansion of the K43 dataset to include other cancers in order to determine incidence, trends, and outcomes of non-HIVAM in Tanzania. We hypothesize that while successful ART improves lifespan of PLWH, but it also lead to an increase in incidence of non-HIVAM, at an earlier chronological age at cancer diagnosis due to HIV associated chronic inflammation and unwanted effects of ART. We will utilize the parent K43 study infrastructure to integrate, and train the early-stage investigator on how to a) design tools for secondary data curation, and b) perform data analysis to determine incidence, trend, and outcome of non-HIVAM among ageing PLWH. This training is significant as it provides a unique opportunity for the trainee to acquire skills in HIV and ageing research. Moreover, the study will foster gender inclusion and diversity in research, motivate others, and improve the multidisciplinary research workforce. Overall, these efforts will generate preliminary data for future studies to understand the impact of HIV and ageing to improve health outcomes for PLWH in SSA.

项目摘要/摘要成功的抗逆转录病毒治疗使艾滋病相关死亡率从2000年代中期的220万下降到1.8 2019年将达到100万。反过来，这又导致了全球人类寿命的延长。在美国，据估计 50%的长寿老人年龄在50岁以上，占长寿老人总死亡人数的70%。这个长沙湾医院的老化人口现正面对与年龄有关的非传染性疾病增加，例如癌症。然而，在撒哈拉以南非洲(SSA)，全球3840万PLWH中约66%居住在那里，数据显示艾滋病毒大流行不断变化的人口统计数据很少。尽管预计非艾滋病毒- 相关恶性肿瘤(HIVAM)增加，并因以下原因而在确诊时更早在公共卫生部门中，艾滋病毒和老龄化对癌症发展的影响的数据有限 SSA。关于老龄化对健康的影响和加速老龄化进程的性质的数据有限部分原因可能是，1)在非洲推广抗逆转录病毒疗法之前，大多数艾滋病人是没有接受过艺术治疗，死得早，很少活到50岁以上。只有通过艺术才能实现 SSA的新一代PLWH现在正在老龄化。2)重要的是，在过去，大多数培训 SSA的机会侧重于对临床医生的培训，以解决患者护理问题，重点放在研究训练。加上研究培训机会有限，特别是在艾滋病毒和老龄化方面，这一点导致SSA的研究产出较低。为了解决训练有素的艾滋病毒研究人员的这一差距，我们正在提议招聘和辅导一名早期女性调查员(Herrieth博士)，介绍艾滋病毒的基础知识通过学术指导和进行实践研究培训来确定坦桑尼亚老年PLWH中非HIVAM的发生率、趋势和结果。总体目标是培训已经确定的年轻、热情的女性早期调查人员，负责扩展K43数据集纳入其他癌症，以确定坦桑尼亚非HIVAM的发病率、趋势和结果。我们假设，虽然成功的抗逆转录病毒疗法可以延长PLWH的寿命，但它也会导致因HIV相关慢性疾病而被诊断为癌症的较早年龄段的非HIVAM发病率炎症和有害的艺术效果。我们将利用母公司K43学习基础设施来集成，并培训早期调查人员如何a)设计用于辅助数据管理的工具，以及b)执行数据分析以确定老年PLWH中非HIVAM的发生率、趋势和结局。这培训意义重大，因为它为受训人员提供了获得艾滋病毒和老龄方面技能的独特机会。研究。此外，这项研究将促进研究中的性别包容性和多样性，激励其他人，以及完善多学科研究队伍。总体而言，这些努力将产生以下初步数据未来的研究以了解艾滋病毒和老龄化的影响，以改善SSA中PLWH的健康结果。