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"Plasma and cellular immune biomarkers of Kaposi's sarcoma in HIV-1 suppressed patients"

“HIV-1 抑制患者中卡波西肉瘤的血浆和细胞免疫生物标志物”

基本信息

批准号：
10871931
负责人：
Salum Juma Lidenge
金额：
$ 10万
依托单位：
MUHIMBILI UNIVERSITY/ ALLIED HLTH SCIS
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10871931
关键词：
Acceleration Acquired Immunodeficiency Syndrome Address Africa Africa South of the Sahara Age Age Years Aging Area Attention Biological Markers Biometry Cancer Patient Caring Cessation of life Child Chronic Chronology Clinical Clinical Research Coupled Data Data Analyses Data Set Development Diagnosis Disease Educational workshop Elderly Electronics Ethics Female Fostering Future Gender Generations Grant HIV HIV Infections HIV Seropositivity HIV-1 HIV/AIDS Health Immunologic Markers Incidence Inequality Inflammation Infrastructure Instruction Interdisciplinary Study Kaposi Sarcoma Life Expectancy Longevity Malignant Neoplasms Manuscripts Mentors Mothers Nature Oceans Outcome Output Parents Patient Care Patients Persons Plasma Population Preparation Prevalence Process Productivity Professional Competence Research Research Design Research Personnel Research Priority Research Training Sample Size Tanzania Time Training United States National Institutes of Health age related aging population antiretroviral therapy cancer diagnosis career co-infection cohort comorbidity data curation demographics design disorder control diversity and inclusion hands on research improved mortality pandemic disease recruit response scale up skill acquisition skills sociodemographics tool training opportunity trend

项目摘要

PROJECT SUMMARY/ABSTRACT Successful ART coverage has has reduced AIDS-related mortality from 2.2 million in mid 2000s to 1.8 million in 2019. In turn, this has led to global increase in life expectancy of PLWH. In the US, it is estimated that 50% of the PLWH are older than 50 years and accounts for 70% of total deaths among PLWH. The ageing population of PLWH is now facing an increase in age-related non-communicable diseases like cancers. However, in sub-Saharan Africa (SSA) where ~66% of global 38.4 million PLWH reside, data on the changing demographics of the HIV pandemic are scarce. Although it is expected that non-HIV- associated malignancies (HIVAM) to increase and at an earlier age at diagnosis as a consequence of ageing among PLWH, there is limited data on the impact of HIV and ageing on cancer development in SSA. The limited data on the impact of ageing on health and the nature of the accelerated ageing process in PLWH in SSA could be partly due to the fact that, 1) prior to ART scale up in Africa, most PLWH were not treated with ART and died at an earlier age, rarely lived beyond 50 years of age. It is only through ART a new generation of PLWH are now ageing in SSA. 2) Importantly, in the past, most of the training opportunities in SSA focused on the training of clinicians to address patient care with minimal emphasis on research training. Coupled with limited research training opportunities, particularly in HIV and ageing, this has led to low research output in SSA. To address this gap of well-trained HIV researchers, we are proposing to recruit and mentor an early-stage female investigator (Dr. Herrieth) on the basics of HIV research through academic instruction and conducting a hands-on research training to determine the incidence, trends, and outcome of non-HIVAM in ageing PLWH in Tanzania. The overall objective is to train the already identified young, enthusiastic female early-stage investigator on expansion of the K43 dataset to include other cancers in order to determine incidence, trends, and outcomes of non-HIVAM in Tanzania. We hypothesize that while successful ART improves lifespan of PLWH, but it also lead to an increase in incidence of non-HIVAM, at an earlier chronological age at cancer diagnosis due to HIV associated chronic inflammation and unwanted effects of ART. We will utilize the parent K43 study infrastructure to integrate, and train the early-stage investigator on how to a) design tools for secondary data curation, and b) perform data analysis to determine incidence, trend, and outcome of non-HIVAM among ageing PLWH. This training is significant as it provides a unique opportunity for the trainee to acquire skills in HIV and ageing research. Moreover, the study will foster gender inclusion and diversity in research, motivate others, and improve the multidisciplinary research workforce. Overall, these efforts will generate preliminary data for future studies to understand the impact of HIV and ageing to improve health outcomes for PLWH in SSA.

项目总结/摘要成功的抗逆转录病毒疗法覆盖率已将艾滋病相关死亡率从2000年代中期的220万降至180万。 2019年百万。这反过来又导致全球艾滋病毒携带者和艾滋病患者的预期寿命延长。在美国，据估计， 50%的艾滋病毒/艾滋病感染者年龄超过50岁，占艾滋病毒/艾滋病感染者死亡总数的70%。的艾滋病病毒携带者的老龄化人口现在面临着与年龄有关的非传染性疾病的增加，癌的然而，在全球3840万艾滋病毒携带者中约66%居住的撒哈拉以南非洲，艾滋病毒流行的人口变化是罕见的。尽管预计非艾滋病毒- 相关恶性肿瘤（HIVAM）增加，并且由于以下原因，诊断时年龄较早由于艾滋病毒携带者的老龄化，有关艾滋病毒和老龄化对癌症发展影响的数据有限特别探员关于老龄化对健康的影响和加速老龄化过程的性质的数据有限在撒哈拉以南非洲的艾滋病毒携带者中，部分原因可能是，1）在非洲扩大抗逆转录病毒疗法之前，大多数艾滋病毒携带者没有接受抗逆转录病毒治疗，在较早的年龄死亡，很少活超过50岁。只有通过艺术在撒南非洲，新一代艾滋病毒携带者正在老化。2)重要的是，在过去， SSA的机会集中在临床医生的培训，以解决病人护理，最小的重点是研究训练。再加上有限的研究培训机会，特别是在艾滋病毒和老龄化方面，导致了SSA的低研究产出。为了解决训练有素的艾滋病毒研究人员的缺口，我们提议招募并指导一名早期女性研究人员（Herrieth博士）了解艾滋病毒的基本知识研究通过学术指导和进行动手研究培训，以确定坦桑尼亚老年艾滋病病毒携带者和艾滋病病毒携带者中非艾滋病毒感染者和艾滋病患者发病率、趋势和结果。总体目标是培训已经确定的年轻，热情的女性早期研究员对K43数据集的扩展包括其他癌症，以确定坦桑尼亚非艾滋病毒感染者的发病率，趋势和结果。我们假设，虽然成功的ART提高了PLWH的寿命，但它也导致了PLWH的增加。非艾滋病毒相关的慢性疾病，在癌症诊断时较早的实际年龄，我们将利用母K43研究基础设施来整合，并培训早期研究人员如何a）设计二级数据管理工具，以及B）执行数据分析，以确定老年PLWH中非HIVAM的发病率、趋势和结局。这培训意义重大，因为它为受训者提供了一个获得艾滋病毒和老龄化方面技能的独特机会 research.此外，这项研究将促进研究中的性别包容性和多样性，激励他人，加强多学科研究队伍建设。总体而言，这些努力将产生初步数据，未来的研究，以了解艾滋病毒和老龄化的影响，以改善卫生成果的艾滋病毒感染者在撒哈拉以南非洲。