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"Plasma and cellular immune biomarkers of Kaposi's sarcoma in HIV-1 suppressed patients"

“HIV-1 抑制患者中卡波西肉瘤的血浆和细胞免疫生物标志物”

基本信息

批准号：
10871931
负责人：
Salum Juma Lidenge
金额：
$ 10万
依托单位：
MUHIMBILI UNIVERSITY/ ALLIED HLTH SCIS
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10871931
关键词：
Acceleration Acquired Immunodeficiency Syndrome Address Africa Africa South of the Sahara Age Age Years Aging Area Attention Biological Markers Biometry Cancer Patient Caring Cessation of life Child Chronic Chronology Clinical Clinical Research Coupled Data Data Analyses Data Set Development Diagnosis Disease Educational workshop Elderly Electronics Ethics Female Fostering Future Gender Generations Grant HIV HIV Infections HIV Seropositivity HIV-1 HIV/AIDS Health Immunologic Markers Incidence Inequality Inflammation Infrastructure Instruction Interdisciplinary Study Kaposi Sarcoma Life Expectancy Longevity Malignant Neoplasms Manuscripts Mentors Mothers Nature Oceans Outcome Output Parents Patient Care Patients Persons Plasma Population Preparation Prevalence Process Productivity Professional Competence Research Research Design Research Personnel Research Priority Research Training Sample Size Tanzania Time Training United States National Institutes of Health age related aging population antiretroviral therapy cancer diagnosis career co-infection cohort comorbidity data curation demographics design disorder control diversity and inclusion hands on research improved mortality pandemic disease recruit response scale up skill acquisition skills sociodemographics tool training opportunity trend

项目摘要

PROJECT SUMMARY/ABSTRACT Successful ART coverage has has reduced AIDS-related mortality from 2.2 million in mid 2000s to 1.8 million in 2019. In turn, this has led to global increase in life expectancy of PLWH. In the US, it is estimated that 50% of the PLWH are older than 50 years and accounts for 70% of total deaths among PLWH. The ageing population of PLWH is now facing an increase in age-related non-communicable diseases like cancers. However, in sub-Saharan Africa (SSA) where ~66% of global 38.4 million PLWH reside, data on the changing demographics of the HIV pandemic are scarce. Although it is expected that non-HIV- associated malignancies (HIVAM) to increase and at an earlier age at diagnosis as a consequence of ageing among PLWH, there is limited data on the impact of HIV and ageing on cancer development in SSA. The limited data on the impact of ageing on health and the nature of the accelerated ageing process in PLWH in SSA could be partly due to the fact that, 1) prior to ART scale up in Africa, most PLWH were not treated with ART and died at an earlier age, rarely lived beyond 50 years of age. It is only through ART a new generation of PLWH are now ageing in SSA. 2) Importantly, in the past, most of the training opportunities in SSA focused on the training of clinicians to address patient care with minimal emphasis on research training. Coupled with limited research training opportunities, particularly in HIV and ageing, this has led to low research output in SSA. To address this gap of well-trained HIV researchers, we are proposing to recruit and mentor an early-stage female investigator (Dr. Herrieth) on the basics of HIV research through academic instruction and conducting a hands-on research training to determine the incidence, trends, and outcome of non-HIVAM in ageing PLWH in Tanzania. The overall objective is to train the already identified young, enthusiastic female early-stage investigator on expansion of the K43 dataset to include other cancers in order to determine incidence, trends, and outcomes of non-HIVAM in Tanzania. We hypothesize that while successful ART improves lifespan of PLWH, but it also lead to an increase in incidence of non-HIVAM, at an earlier chronological age at cancer diagnosis due to HIV associated chronic inflammation and unwanted effects of ART. We will utilize the parent K43 study infrastructure to integrate, and train the early-stage investigator on how to a) design tools for secondary data curation, and b) perform data analysis to determine incidence, trend, and outcome of non-HIVAM among ageing PLWH. This training is significant as it provides a unique opportunity for the trainee to acquire skills in HIV and ageing research. Moreover, the study will foster gender inclusion and diversity in research, motivate others, and improve the multidisciplinary research workforce. Overall, these efforts will generate preliminary data for future studies to understand the impact of HIV and ageing to improve health outcomes for PLWH in SSA.

项目总结/文摘