TB/MDR-TB Research training and Capacity Strengthening for LMIC in Southeast Asia Phase II: End-of-Fiscal-Year Supplement

项目摘要/摘要 结核病/耐多药结核病是一个严重的全球卫生问题。东南亚是一个受此影响很大的地区 疾病。为了实现消灭结核病的目标，必须加强对结核病的研究。 我们的D43TW009522资助“结核病/耐多药结核病研究能力加强计划”的目标是 东南亚，第二阶段“是加强结核病研究能力，特别是结核病人力资源 研究，在LMIC合作研究中心和国家结核病控制计划(NTP) 缅甸、泰国和印度尼西亚。 自2015年以来，我们有效地培养了这三个国家的一系列青年科研人员。 受训人员来自合作中心，他们成功地返回自己的国家工作。 然而，2021年缅甸出现了严重的政治动荡。研究设施和人力资源 资源中断。我们的大多数校友不能继续在这个国家工作。有一个 需要尝试不同的方法，包括间接方法，以聚集人力资源 研究。当政治形势变得更加有利时，该国的研究就可以恢复其 势头。 我们资助的两名缅甸校友现在流行病学系从事博士后工作 结核病研究方面的研究员。支持这些科学家进一步成长至少可以在一定程度上维持人类 D43TW009522投资的结核病研究资源。 在宋卡亲王大学流行病学系(EPI-PSU)，结核病研究项目有 不断发展，以服务于国家和全球需求。我们一直在与 结核病司(DTB)比以前。我们的结核病研究范围已经扩大到包括国家 关于卫生系统的大数据，其中包括结核病。泰国将进行常规的全基因组测试 对所有结核分枝杆菌分离株进行测序。结核病控制在#年变得更加密集 结核病潜伏感染的筛查和治疗。这些国家和机构在结核病方面的扩张 研究需要更多训练有素的流行病学家参与进来。训练有素的结核病流行病学家 因此缅甸和泰国等国都需要。 我们正在申请年终补充补助金，以支持这两位校友成为我们的博士后 研究员他们将与高级和初级研究人员一起制定研究提案、分析 收集现有数据，准备手稿，撰写有竞争力的研究补助金。两项主要研究 他们要完成的课题包括结核病后研究和结核病接触中管理差距的分析 追踪。由于PSU正在推动负责任的研究政策和实践，他们将研究 加入这项任务。在我们的监督下，他们将适当地加入全国结核病流行情况调查 以及改善国家结核病数据库的项目。 D43TW009522的PI Virasakdi Chung suvivatwong教授将成为他们的主要导师，并将与 EPI-PSU和Mahidol大学的高级教员。 对博士后培训的年度评估将遵循巴黎州立大学博士后研究所制定的程序 计划，强调同行评议的科学出版物。

Project Summary/Abstract TB/MDR-TB is a serious global health problem. Southeast Asia is a region heavily affected by this disease. To achieve the END-TB goal, research on TB must be enhanced. The objective of our D43TW009522 grant "TB/MDR-TB Research capacity strengthening program for Southeast Asia, Phase II" is to strengthen TB research capacity, especially human resources for TB research, at LMIC collaborating research centers and the National TB Control Program (NTP) in Myanmar, Thailand, and Indonesia. Since 2015, we have been training a series of young researchers from these three countries effectively. The trainees were from the collaborating centers, who return to work in their countries successfully. However, there has been a serious political turmoil in Myanmar in 2021. Research facilities and human resources are interrupted. Most of our alumni could not continue to work in the country. There is a need to try different methods, including indirect approaches, to assemble human resources for research. When the political situation turns more favorable, research in the country can then regain its momentum. Two Myanmar alumni of our grant are now working at the Department of Epidemiology as postdoctoral fellows on TB research. Supporting these scientists to grow further can at least partially maintain human resources for TB research that D43TW009522 had invested. At the Department of Epidemiology, Prince of Songkla University (EPI-PSU), TB research projects are growing to serve the national and global needs. We have been working more intensively with the Division of Tuberculosis (DTB) than before. Our scope of TB research has expanded to include National Big Data on the health system, which includes TB. Thailand is going to do routine whole genome sequencing on all isolates of Mycobacterium tuberculosis. TB control has become more intensive in screening and treatment of latent TB infections. These national and institutional expansions in TB research require more well-trained epidemiologists to get involved. Well-trained TB epidemiologists are therefore needed by both Myanmar and Thailand and other countries. We are requesting the end-of-year supplement grant to support these two alumni as our postdoctoral fellows They will work with the senior and junior researchers in developing research proposals, analysis of existing data, preparing manuscripts, and writing competitive research grants. Two main research topics to be accomplished by them include post-TB study and analysis of management gap in TB contact tracing. As PSU is pushing Responsible Conduct of Research policy and practice, they will do research on join this mission. Under our supervision, they will appropriately join the National TB prevalence survey and the Project to improve the National TB database. Professor Virasakdi Chongsuvivatwong, the PI of D43TW009522, will be their main mentor and joined by the senior faculty members of EPI-PSU and Mahidol University. Annual evaluation of this post-doctoral training will follow the procedures set by PSU’s Post-doctoral Program, which emphasizes peer-reviewed scientific publication.