TB/MDR-TB Research training and Capacity Strengthening for LMIC in Southeast Asia Phase II: End-of-Fiscal-Year Supplement

项目总结/摘要 结核病/耐多药结核病是一个严重的全球健康问题。东南亚是受此影响严重的地区 疾病为了实现终结结核病的目标，必须加强对结核病的研究。 我们的D43 TW 009522赠款“结核病/耐多药结核病研究能力加强计划”的目标是： 东南亚，第二阶段”是加强结核病研究能力，特别是结核病的人力资源 研究，在LMIC合作研究中心和国家结核病控制计划（NTP）， 缅甸、泰国和印度尼西亚。 自2015年以来，我们一直在有效地培训来自这三个国家的一系列年轻研究人员。 受训人员来自各合作中心，他们成功地返回各自国家工作。 然而，2021年缅甸发生了严重的政治动荡。研究设施和人类 资源中断。我们的大多数校友不能继续在该国工作。有一个 需要尝试不同的方法，包括间接的方法，以汇集人力资源， research.当政治局势变得更加有利时，该国的研究可以重新获得其 势头. 我们的两名缅甸校友现在在流行病学系担任博士后 结核病研究的研究员支持这些科学家进一步发展至少可以部分维持人类 D43 TW 009522投入的结核病研究资源。 在宋卡王子大学流行病学系（EPI-PSU）， 不断发展，以满足国家和全球的需求。我们一直在更深入地与 结核病科（DTB）比以前。我们的结核病研究范围已扩大到包括国家 关于卫生系统的大数据，包括结核病。泰国将进行常规的全基因组测序 对所有结核分枝杆菌分离株进行测序。结核病控制已变得更加密集， 筛查和治疗潜伏性结核病感染。这些国家和机构在结核病方面的扩张 研究需要更多训练有素的流行病学家参与。训练有素的结核病流行病学家 因此，缅甸和泰国以及其他国家都需要。 我们正在申请年终补助金，以支持这两位校友担任我们的博士后 他们将与高级和初级研究人员一起制定研究计划，分析 现有的数据，准备手稿，并编写有竞争力的研究赠款。两个主要研究 他们将完成的课题包括结核病后研究和结核病接触者管理差距分析 追踪由于PSU正在推动研究政策和实践的负责任行为，他们将研究 加入这个使命。在我们的监督下，他们将适当地参加全国结核病患病率调查 以及改进国家结核病数据库项目。 Virasakdi Chongsuvivatwong教授，D43 TW 009522的PI，将是他们的主要导师，并加入了 EPI-PSU和玛希隆大学的高级教师。 本博士后培训的年度评估将遵循PSU的博士后设置的程序 该计划强调同行评审的科学出版物。

Project Summary/Abstract TB/MDR-TB is a serious global health problem. Southeast Asia is a region heavily affected by this disease. To achieve the END-TB goal, research on TB must be enhanced. The objective of our D43TW009522 grant "TB/MDR-TB Research capacity strengthening program for Southeast Asia, Phase II" is to strengthen TB research capacity, especially human resources for TB research, at LMIC collaborating research centers and the National TB Control Program (NTP) in Myanmar, Thailand, and Indonesia. Since 2015, we have been training a series of young researchers from these three countries effectively. The trainees were from the collaborating centers, who return to work in their countries successfully. However, there has been a serious political turmoil in Myanmar in 2021. Research facilities and human resources are interrupted. Most of our alumni could not continue to work in the country. There is a need to try different methods, including indirect approaches, to assemble human resources for research. When the political situation turns more favorable, research in the country can then regain its momentum. Two Myanmar alumni of our grant are now working at the Department of Epidemiology as postdoctoral fellows on TB research. Supporting these scientists to grow further can at least partially maintain human resources for TB research that D43TW009522 had invested. At the Department of Epidemiology, Prince of Songkla University (EPI-PSU), TB research projects are growing to serve the national and global needs. We have been working more intensively with the Division of Tuberculosis (DTB) than before. Our scope of TB research has expanded to include National Big Data on the health system, which includes TB. Thailand is going to do routine whole genome sequencing on all isolates of Mycobacterium tuberculosis. TB control has become more intensive in screening and treatment of latent TB infections. These national and institutional expansions in TB research require more well-trained epidemiologists to get involved. Well-trained TB epidemiologists are therefore needed by both Myanmar and Thailand and other countries. We are requesting the end-of-year supplement grant to support these two alumni as our postdoctoral fellows They will work with the senior and junior researchers in developing research proposals, analysis of existing data, preparing manuscripts, and writing competitive research grants. Two main research topics to be accomplished by them include post-TB study and analysis of management gap in TB contact tracing. As PSU is pushing Responsible Conduct of Research policy and practice, they will do research on join this mission. Under our supervision, they will appropriately join the National TB prevalence survey and the Project to improve the National TB database. Professor Virasakdi Chongsuvivatwong, the PI of D43TW009522, will be their main mentor and joined by the senior faculty members of EPI-PSU and Mahidol University. Annual evaluation of this post-doctoral training will follow the procedures set by PSU’s Post-doctoral Program, which emphasizes peer-reviewed scientific publication.