CANCAN-RUTGERS

癌症恶病质（CC）是一种系统性代谢消耗综合征，以骨骼肌和脂肪组织消耗导致体重减轻为特征。约80%的癌症患者患有CC，导致工作状态下降，对化疗不耐受，死亡率增加。人们对这种使人衰弱的疾病知之甚少，也没有有效的治疗方法。如果CC疗法存在，它将改善治疗反应，提高生活质量，延长生存期。经过50年的研究，该领域一直专注于确定在最影响我的恶病质的最终器官中促进萎缩的途径。虽然这项工作已经取得了成果，但它并没有导致CC的上游介质的鉴定，也没有产生有效的治疗方法。迫切需要高质量的发现科学和更详细的临床表型。我们创建了一个虚拟研究所，由不同的、国际化的、多学科的科学家和临床医生组成，他们在癌症、代谢、神经内分泌功能、免疫学、人类代谢疾病、临床前模型和临床表型方面具有专业知识。我们假设CC是由激活神经激素疾病途径的肿瘤内在因素驱动的，从而导致厌食症、代谢功能障碍和组织萎缩。

Cancer cachexia (CC) is a systemic, metabolic wasting syndrome featuring body weight loss due to skeletal muscle and adipose tissue wasting. CC is suffered by ~80% of cancer patients that causes reduced performance status, intolerance to chemotherapy, and increased mortality. This debilitating condition is poorly understood and has no effective treatment. If CC therapy existed, it would improve treatment responses, increase quality of life, and prolong survival. With 50 years of study, the field has focused on defining pathways that promote atrophy in the end-organs most affected my cachexia. While this work has been fruitful, it has not led to identification of the upstream mediators of CC, nor has it generated effective therapies. There is an urgent need for high-quality discovery science and more detailed clinical phenotyping.We have created a virtual institute comprised of diverse, international, multidisciplinary scientists and clinicians with expertise in cancer, metabolism, neuroendocrine function, immunology, human metabolic diseases, preclinical models, and clinical phenotyping. We hypothesize that CC is driven by tumor-intrinsic factors that activate neurohormonal sickness pathways, which then induce anorexia, metabolic dysfunction, and tissue atrophy.