Stanford MoTrPAC Bioinformatics Center

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Abstract Few interventions have been shown to be as beneficial to human health as physical activity, yet we remain largely ignorant of the mechanisms by which these potent health effects are transduced. The Molecular Transducers of Physical Activity Consortium examines the response to acute and chronic exercise at multiple scales and in multiple tissues across thousands of humans and in animal models. MoTrPAC combines multi-scale phenotyping with molecular multi-omics approaches. Building on our long history of analytical innovation in high throughput biology and computational innovation, the Stanford MoTrPAC Bioinformatics Center will provide computational, bioinformatic and analytic expertise to the Consortium. Leveraging scalability and reproducibility approaches enabled by cloud architecture, we provide a robust platform for the sharing and analysis of multi-tissue, multi-omic, physiological and sensor based measurement data. Aim 1 is focused on advancing our cloud-based data warehouse for raw and processed data. We will achieve this by extending work enabling data access and data processing, advancing data management and scalable search. Aim 2 implements existing omics pipelines and the development of new pipelines for human multi-omic data. In addition, we extend analytic approaches for multi-scale, high-throughput data from human and animal studies. We will expand robust data analysis pipelines and code repositories built with FAIR principles in mind. In addition, we will continue incorporating data integration and novel visualization approaches. Aim 3 expands and extends our interactive interface for investigators and the public to interrogate, interact with, explore, and download MoTrPAC data. In addition, deposition of MoTrPAC data to durable, public repositories and of code and analysis packages to public collaboratories, together with dissemination activities developed by the BIC on behalf of the Consortium will extend the utility and utilization of the work of the Consortium to advance the science of physical activity. With the expertise, experience, infrastructure and tools already in place, the Stanford MoTrPAC Bioinformatics Center is well-positioned to deliver on the vision of MoTrPAC, from data collection, processing and analysis to exploration and dissemination.