NEUROIMAGING IN HUNTINGTONS DISEASE

亨廷顿病的神经影像学

• 批准号: 6243503
• 负责人: ELIZABETH H AYLWARD
• 金额: $ 19.25万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 1997-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6243503
• 关键词: Huntington's disease; brain imaging /visualization /scanning; cerebral degeneration; histopathology; human subject; longitudinal human study; magnetic resonance imaging; neuroanatomy; neurophysiology; neuropsychological tests; nucleic acid repetitive sequence

The purpose of the proposed Neuroimaging Project is to use quantitative measures from MRI to chart the longitudinal course of atrophy in specific brain structures in patients with Huntington's Disease. In conjunction with Project (Neuropsychology) and Core (Clinical), we will also determine the association between these neuroanatomical changes and longitudinal changes in neuropsychological functioning and clinical symptomatology. We will obtain MRI scans on 150 patients with Huntington's Disease, and on 150 individually matched control subjects. Patients will be scanned every two years using the same standardized MRI protocol. MRI measurements will include volumes of basal ganglia (caudate, putamen, globus pallidus), brain stem, cerebellum, and comparison regions, as well as total gray, white, and CSF volumes, and volumes of specific cortical regions. MRI measures will be correlated and neuropsychological measures obtained at the same visit. We hypothesize that MRI measures of specific brain regions will correlate with specific neuropsychological functions, clinical variables, and length of trinucleotide repeat for the HD patients. Longitudinal changes in MRI measures will also be analyzed. We hypothesize that atrophy in various regions of the brain will progress at different rates during the course of the illness. We also hypothesize that rate of atrophy in specific brain regions will be correlated with rate of decline in specific neuropsychological functions. This project will provide the first systematic view of atrophy in several specific brain regions within the same HD patients over time. By comparing decline in specific neuropsychological functions and clinical symptoms with atrophy in specific regions that may deteriorate at different rates and at different points during the course of the illness, we will be able to provide a more complete picture of brain-behavior relationships in HD.

拟议的神经成像项目的目的是使用量化 MRI对特发性脑萎缩纵向病程的诊断 亨廷顿病患者的脑结构。结合 通过Project(神经心理学)和Core(临床)，我们还将确定 这些神经解剖变化与纵向的关系 神经心理功能和临床症状的变化。我们 将对150名亨廷顿病患者和150名亨廷顿病患者进行核磁共振扫描 单独匹配的对照组受试者。患者将每两次扫描一次 多年来使用相同的标准化磁共振成像方案。核磁共振测量将会 包括体积基底节(尾状核、壳核、苍白球)、脑 茎、小脑和对照区域，以及总的灰色、白色和 脑脊液体积和特定皮质区域的体积。核磁共振措施将 相互关联，并在同一次访问中获得神经心理测量。 我们假设特定大脑区域的核磁共振测量将与 具有特定的神经心理功能、临床变量和长度 HD患者的三核苷酸重复序列。磁共振成像中的纵向变化 还将分析措施。我们假设在不同的情况下萎缩 在这个过程中，大脑的不同区域会以不同的速度发展 他的病。我们还假设特定大脑的萎缩速度 地区将与特定地区的下降速度相关 神经心理功能。该项目将提供第一个 对大脑中几个特定区域萎缩的系统观察 随着时间的推移，同样的HD患者。通过比较特定领域的下降 特发性萎缩的神经心理功能和临床症状 可能以不同的速度和不同的时间点恶化的地区 在疾病期间，我们将能够提供更多的 高清中大脑-行为关系的完整图景。