MOLECULAR GENETIC OF SCHIZOPHRENA AND MANIC DEPRESSION

精神分裂症和躁狂抑郁症的分子遗传学

• 批准号: 2392832
• 负责人: William Byerley
• 金额: $ 9.06万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 1998-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2392832
• 关键词: autoradiography; bipolar depression; complementary DNA; dopamine receptor; family genetics; gene frequency; genetic markers; genome; genotype; human data; human subject; interview; linkage mapping; nucleic acid repetitive sequence; polymerase chain reaction; radiotracer; restriction fragment length polymorphism; schizophrenia

Schizophrenia (SCZ) and Manic-Depressive Illness (MDI) are devastating psychiatric syndromes, affecting at least 1% of the American population. Family, twin and adoption studies conducted over the past half century consistently implicate heredity in the pathogenesis of these illnesses. Linkage analyses with DNA markers - coupled with novel candidate gene studies - holds great promise to elucidate the genetics of neurobiology of some forms of SCZ and MDI. Previous grant support, from both private and ADAMHA sources, has allowed Dr. Byerley to ascertain 12 multiplex schizophrenia pedigrees as well as 12 high density bipolar families. During the course of this work, Dr. Byerley conducted over 500 SADS-L interviews and over 150 follow-up SADS-L interviews. In addition, Dr. Byerley coordinated candidate gene studies (e.g., the D1, D2, D3, D4, and D5 dopamine receptors) as well as genome scanning techniques in a subset of pedigrees. The primary aim of Dr. Byerley's work is to test the hypothesis that major loci underlie SCZ and MDI in a subgroup of families. this will be carried out by (1) ascertaining at least eight additional SCZ pedigrees as well as eight MDI families and (2) genotyping studies with highly polymorphic simple sequence repeat markers, polymorphic brain cDNAs, and selected candidate genes.

精神分裂症（SCZ）和躁狂抑郁症（MDI）是毁灭性的

项目成果

Manic-depression and the norepinephrine transporter gene.

躁狂抑郁症和去甲肾上腺素转运蛋白基因。

• DOI: 10.1159/000154279
• 发表时间: 1995
• 期刊: Human heredity
• 影响因子: 1.8
• 作者: Hadley,D;Hoff,M;Holik,J;Reimherr,F;Wender,P;Coon,H;Byerley,W
• 通讯作者: Byerley,W

A linkage study with D5 dopamine and alpha 2C-adrenergic receptor genes in six multiplex bipolar pedigrees.

六个多重双相谱系中 D5 多巴胺和 α2C 肾上腺素受体基因的连锁研究。

• DOI: 10.1097/00041444-199400430-00001
• 发表时间: 1994
• 期刊: Psychiatric genetics
• 影响因子: 0.9
• 作者: Byerley,W;Hoff,M;Holik,J;Coon,H
• 通讯作者: Coon,H

Schizophrenia and glutamate receptor genes.

精神分裂症和谷氨酸受体基因。

• DOI: 10.1097/00041444-199400430-00006
• 发表时间: 1994
• 期刊: Psychiatric genetics
• 影响因子: 0.9
• 作者: Pariseau,C;Gregor,P;Myles-Worsley,M;Holik,J;Hoff,M;Waldo,M;Freedman,R;Coon,H;Byerley,W
• 通讯作者: Byerley,W

Dinucleotide repeat polymorphism in the human taurine transporter gene (TAUT).

人牛磺酸转运蛋白基因 (TAUT) 中的二核苷酸重复多态性。

• DOI: 10.1093/hmg/3.12.2263
• 发表时间: 1994
• 期刊: Human molecular genetics
• 影响因子: 3.5
• 作者: Gregor,P;Hoff,M;Holik,J;Hadley,D;Fang,N;Coon,H;Byerley,W
• 通讯作者: Byerley,W

Search for a schizophrenia susceptibility gene on chromosome 18.

在 18 号染色体上寻找精神分裂症易感基因。

• DOI: 10.1097/00041444-199521000-00005
• 发表时间: 1995
• 期刊: Psychiatric genetics.
• 作者: Fang,N;Coon,H;Hoff,M;Holik,J;Hadley,D;Reimherr,F;Wender,P;Myles-Worsley,M;Waldo,M;Freedman,R
• 通讯作者: Freedman,R