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FUNCTIONAL ANALYSIS OF RBAP2

FUNCTIONAL ANALYSIS OF RBAP2
RBAP2的功能分析
批准号：
2390851
负责人：
WILLIAM R SELLERS
金额：
$9.08万
依托单位：
DANA-FARBER CANCER INST
依托单位国家：
美国
项目类别：
财政年份：
1995
资助国家：
美国
项目状态：
已结题
起止时间：
1995-04-01 至 2000-03-31
来源：
https://reporter.nih.gov/project-details/2390851
关键词：
DNA binding protein binding proteins cell cycle cell growth regulation flow cytometry molecular cloning phosphoproteins polymerase chain reaction protein structure function protooncogene retinoblastoma protein transcription factor tumor suppressor genes

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英文摘要
We have cloned a protein, RBAP2, based upon its ability to bind to the retinoblastoma gene product in vitro. We have extended the clone to full- length status, shown that it is a nuclear phospho- protein, and that it binds to RB in vivo. This binding follows the same genetics as has been established for the interaction of RB and the viral oncoproteins large T antigen, E1A, and E7. This grant now proposes to investigate the biochemical and biological functions of RBAP2 and, in addition, the role of RBAP2 in RB mediated cell-cycle regulation.
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