课题基金 / 基金详情

CANDIDATE GENES WITH TRIMERIC REPEATS IN NEUROPSYCHIATRY

CANDIDATE GENES WITH TRIMERIC REPEATS IN NEUROPSYCHIATRY
神经精神病学中具有三聚体重复的候选基因
批准号：
2415748
负责人：
MELVIN G MCINNIS
金额：
$15.57万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
项目状态：
已结题
起止时间：
1994-05-01 至 1999-04-30
来源：
https://reporter.nih.gov/project-details/2415748
关键词：
bipolar depression computer assisted sequence analysis family genetics gene expression genetic library genetic markers genetic polymorphism human genetic material tag human tissue linkage mapping molecular cloning neuropsychology nucleic acid repetitive sequence polymerase chain reaction

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中文摘要
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英文摘要
My research plan is driven by the general hypothesis that genes with trinucleotide repeats (TNRs) are expressed in brain and when they under expansion, cause neuropsychiatric disease. It is known that genes containing TNRs are frequently polymorphic and are to that extent valuable as linkage markers. My research development plan builds on my present skills of linkage mapping and extends them to gene cloning and expression analysis. My long term career plans are to identify, characterize and study genes involved with psychiatric disease. I will identify and characterize cDNA clones containing TNRs and will map these repeats and examine bipolar affective disorder family members for evidence of expansion.
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会议论文
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