HETEROANNULATION OF HYDROQUINONES WITH ALKYNES/AMINES

氢醌与炔烃/胺的杂环化

• 批准号: 2193677
• 负责人: WILEY J YOUNGS
• 金额: $ 11.03万
• 依托单位: UNIVERSITY OF AKRON
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-06-01 至 1999-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2193677
• 关键词: alkynes; amines; chemical bond; chemical synthesis; cyclization; hydroquinones; indoles

During the course of an investigation of the synthesis of quinone derivatives of cyclynes and cyclodiynes, we have discovered several novel processes expected to have utility in the synthesis of natural products, polymers and new ligands for transition and main group elements. These reactions include: (a) intramolecular cyclization of alkynylhydroquinones to polycyclic systems, (b)the production of indoloquinones from the combination of 2,3-diiodo- 4,5-dimethylhydroquinone with amines, (c) the activation of the methyl groups of 2,3-diiodo-4,5-dimethylhydroquinone to give novel bidentate bisamine ligands, and (d) the formation of isoindoloquinones from the interaction of a diethynylhydroquinone with amines. The exploration and development of these novel reactions is the goal of this research project.

在研究醌的合成过程中， 环炔和环二炔的衍生物，我们已经发现了几种新的 预期可用于合成天然产物的方法， 聚合物和过渡族和主族元素的新配体。这些 反应包括：（a）炔基氢醌的分子内环化 （B）从多环体系制备吲哚醌， 2，3-二碘-4，5-二甲基氢醌与胺的组合，（c） 活化2，3-二碘-4，5-二甲基氢醌的甲基， 得到新的双齿双胺配体，和（d）形成 二乙炔基氢醌与 胺。对这些新反应的探索和发展， 这个研究项目的目标。