Novel regulators of phosphate homeostasis in phosphate wasting disorders

磷酸盐消耗性疾病中磷酸盐稳态的新型调节剂

• 批准号: nhmrc : 107251
• 负责人: Prof Rebecca Mason
• 金额: $ 23.84万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-regulators-phosphate-wasting-disorders/100918
• 关键词: Novel; regulators; phosphate; homeostasis; wasting

This project investigates two phosphate wasting disorders - tumour-associated osteomalacia and inherited X-linked low phosphate rickets. The active factor responsible for the tumour-associated condition remains unidentified and despite isolation of the gene responsible, the mechanism of the inherited rickets is also unexplained . The proposed outcomes of this project address both these issues. Whilst the condition of the tumour-associated osteomalacia is relatively uncommon, it continues to be a clinical problem because its presentation is often non-specific and the tumour is often very difficult to find. To date our studies have helped in the identification of patients likely to have the condition. Furthermore, while the phosphate wasting factor may be produced in abnormally large amounts by the tumour in this condition, it is likely that the factor and the enzyme which may be associated with it have physiological roles in maintaining normal phosphate concentrations. Looking further ahead, the phosphate wasting factor may have a clinical use in patients with renal failure and phosphate retention.

这个项目调查了两种磷酸盐消耗障碍--肿瘤相关的骨软化症和遗传性X连锁低磷酸盐软骨病。导致肿瘤相关疾病的活跃因素仍未确定，尽管分离出了相关基因，但遗传性软骨病的机制也尚不清楚。该项目的拟议成果解决了这两个问题。虽然与肿瘤相关的骨软化症相对少见，但它仍然是一个临床问题，因为它的表现通常是非特异性的，而且肿瘤通常很难发现。到目前为止，我们的研究已经帮助确定了可能患有这种疾病的患者。此外，虽然在这种情况下，肿瘤可能会异常大量地产生磷酸盐消耗因子，但该因子和可能与其相关的酶很可能在维持正常的磷酸盐浓度方面具有生理作用。展望未来，磷酸盐消耗因子可能在肾功能衰竭和磷酸盐滞留患者中有临床应用。