Does muscle contribute to the maintenance of vitamin D status in winter?

冬季肌肉是否有助于维持维生素 D 状态？

• 批准号: DP170104408
• 负责人: Prof Rebecca Mason
• 金额: $ 27.43万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170104408
• 关键词: Does; muscle; contribute; maintenance; vitamin

This project aims to test the mechanism by which vitamin D status is maintained in winter when input is low. The long half-life in blood of the vitamin D metabolite, 25-hydroxyvitamin D [25(OH)D], maintains an adequate vitamin D status over winter, when sunlight, which produces vitamin D in skin, is reduced. From preliminary data in sheep and mice, this project proposes that skeletal muscle, not fat, stores vitamin D. This project will test this hypothesis in sheep, cultured muscle cells and in transgenic mice. The project will confirm whether the processes identified in skeletal muscle contribute to the maintenance of vitamin D status, and identify ways of enhancing this process.

本项目旨在测试维生素D在冬季低输入时维持状态的机制。维生素D代谢产物25-羟基维生素D [25(OH)D]在血液中的半衰期很长，在冬季，当皮肤中产生维生素D的阳光减少时，维持足够的维生素D状态。从绵羊和小鼠的初步数据来看，该项目提出是骨骼肌而不是脂肪储存维生素d。该项目将在绵羊、培养的肌肉细胞和转基因小鼠身上验证这一假设。该项目将确认在骨骼肌中发现的过程是否有助于维持维生素D状态，并确定增强这一过程的方法。