Novel roles for neural crest cells in cardiac morphogenesis

神经嵴细胞在心脏形态发生中的新作用

• 批准号: nhmrc : GNT1144004
• 负责人: A/Pr Quenten Schwarz
• 金额: $ 55.38万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-roles-neural-cardiac-morphogenesis/1348571
• 关键词: Novel; roles; neural; crest; cells

Abnormal formation of the cardiac outflow tract leads to common malformations affecting over 1% of all births. Taking advantage of novel mouse models this grant aims to identify the molecular mechanisms by which neural crest cells control formation of the cardiac outflow tract. New information generated from this study stands to identify new targets which may be used for predictive testing and regenerative therapies.

心脏流出道的异常形成导致常见的畸形，影响所有出生的1%以上。利用新的小鼠模型，该基金旨在确定神经嵴细胞控制心脏流出道形成的分子机制。这项研究产生的新信息有助于确定可用于预测性测试和再生疗法的新靶点。