INTERFACE FAILURE IN TOTAL JOINT REPLACEMENTS

描述（改编自申请人摘要）：无菌性松动 仍然是全髋关节置换术的问题。 骨水泥型总计 髋关节置换术后，机械性松动最常始于 股骨柄-骨水泥或骨水泥-骨界面。 虽然人们普遍认为 在骨水泥-骨界面处需要强壮的骨， 骨水泥型股骨部件的骨水泥-金属界面存在争议。 一 提出了研究方案，以调查：1）具体的机械 股骨柄-骨水泥和骨水泥-骨界面的条件 2）接口失效导致机械故障的方式 骨水泥型股骨髋关节假体松动;以及3）使用这种 “优化”股骨柄-骨水泥粘合的位置和范围的信息， 降低植入物失效的风险。 这里，“结合”用于描述任何 增强股骨柄-骨水泥界面（机械粗糙化或PMMA预涂层）， 与光滑的未结合界面相比。 这是一个假设 股骨柄-骨水泥界面结合的方式和程度 影响植入物的整体失效（松动）。 进一步 假设一些“最佳”配置，包括区域， 杆被结合，而杆未被结合的区域将导致 植入物的长期性能显著提高。

DESCRIPTION (Adapted from the Applicant's Abstract): Aseptic loosening continues to be a problem with total hip replacements. In cemented total hip replacement, mechanically induced loosening most often initiates at the stem-cement or cement-bone interface. And while it is widely accepted that a strong bone is desirable at the cement-bone interface, the optimal cement-metal interface is disputed for cemented femoral components. A research program is proposed to investigate: 1) the specific mechanical conditions under which the femoral stem-cement and cement-bone interfaces fail; 2) the manner in which interface failure contributes to mechanical loosening of cemented femoral hip components; and 3) the use of this information to "optimize" the locations and extent of stem-cement bonding to reduce the risk of implant failure. Here, "bonding" is used to describe any enhanced stem-cement interface (mechanically roughened or PMMA precoated), as compared to a smooth unbonded interface. It is the hypothesis of this work that the manner and extent of bonding of the stem-cement interface affects the overall failure (loosening) of the implant. It is further hypothesized that some "optimum" configuration, consisting of regions where the stem is bonded, and regions where the stem is unbonded, will result in a significant increase in the long-term performance of the implant.