MODEL FOR EXPERIMENTAL STUDIES OF FACIAL MUSCLES

面部肌肉实验研究模型

• 批准号: 3425397
• 负责人: LAWRENCE WINESKI
• 金额: $ 2.03万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-04-01 至 1990-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3425397
• 关键词: facial muscles; guinea pigs; hamsters; histochemistry /cytochemistry; laboratory rat; motor neurons; muscle function; neuromuscular function; neurophysiology; tissue /cell preparation

The objective of this project is to generate preliminary data testing the vibrissal motor system (VMS) of rodents as a model for experimental studies of the facial muscles in the orofacial region. This will be accomplished by employing three representative species (golden hamster, rat, guinea pig) to test the general hypothesis that different types of orofacial behavior (e.g., different categories of vibrissal movement) reflect different patterns of organization of the facial muscles. Two specific aims are designed to test two specific hypotheses regarding likely levels of organization. Hypothesis (1) is that homologous facial muscles with different specific actions have different physiological properties. To test this, Specific Aim (1) is to examine the histochemical fiver type composition of the vibrissal facial muscles in each species, and to compare the three species. Hypothesis (2) is that homologous facial muscles with dissimilar functions have dissimilar patterns of neural organization. To test this, Specific Aim (2) is to map (via horseradish peroxidase labeling) the distributions of the motoneuron cell bodies of the vibrissal facial muscles in the brainstem facial motor nucleus of each species, and to compare the three species. A VMS model of the facial musculature would provide new information on the functional properties of facial muscles. This could be valuable clinically in muscle transposition for orofacial paralysis by enabling better functional matching of the transposed muscle and pretraumatized, normal facial muscles.

该项目的目标是生成初步数据， 啮齿类动物的触须运动系统（VMS）作为实验研究的模型 在面部肌肉的口面部区域。 这将是完成 采用三种代表性物种（金黄仓鼠、大鼠、豚鼠） 来验证不同类型的口面行为 (e.g.,不同种类的触须运动）反映了不同的 面部肌肉的组织模式。 两个具体目标是 旨在测试两个特定的假设， organization. 假设（1）是同源面部肌肉与 不同的具体行动具有不同的生理特性。 到 本试验的具体目的（1）是检测组织化学肝型 在每个物种的触须面部肌肉的组成，并比较 这三个物种。 假设（2）是同源的面部肌肉， 不同的功能具有不同的神经组织模式。 到 测试这一点，具体目标（2）是映射（通过辣根过氧化物酶标记） 面触须运动神经元胞体的分布 肌肉在脑干面部运动核的每一个物种，并 对比一下这三个物种。 面部肌肉组织的VMS模型将 提供了面部肌肉功能特性的新信息。 这对口面部肌肉移位术有一定的临床应用价值 通过使移位肌肉的功能更好地匹配， 和正常的面部肌肉