INTERFACE STRENGTH AND HISTOLOGY--EXPANDABLE TI IMPLANT

界面强度和组织学——可扩展 TI 植入物

• 批准号: 3425413
• 负责人: EDWARD J KARDYS
• 金额: $ 2.29万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-20 至 1989-09-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3425413
• 关键词: biomaterial evaluation; endosseous dental implant; femur; laboratory rabbit; metal dental material; physiologic bone resorption; tensile strength; titanium

The specific aim of this study is to determine the correlation between histologically definable osseointegration and mechanically tested shear interface strength of commercially pure, expandable smooth surface titanium implants. Consequently, a greater number of samples can be evaluated mechanically without studying each one histologically, thus reducing costs. Expandable endosseous implants exert favorable compressive stresses that provide an environment that enhances bone growth onto the prosthesis. Expansion against bone replaces the need for technique sensitive steps such as threading adn tapping which may lead to failure when not precisely adhered to. The long term objective is to demonstrate expandable implants exert an optimal applied compressive level that improves the prognosis of osseointegration, thereby improving the reliability of complete bony union and shortening the healing period prior to complete osseointegration. This will provide greater predictability for a successful functional implant. Cylindrically shaped implants whose diameters increase uniformly when they are expanded are surgically implanted in femus of rabbits. Control implants of the same configuration are subjected to the same implantation techniques. Two different time periods are selected to examine the change in healing and osseou interface that can resist pushout over time. Bone modeling will be observed for implants having 3 different internally applied loads, suboptimal, optimal and supra-optimal. The amount of osseo-integration will be assessed directly by selected histologic samples and predicted indirectly by the relative level of interface strength. Implantation techniques will follow the principles recommended by P-I. Branemark. Histologic samples will be decalcified and prepared for sectioning before observing under light microscope. The sheer interface strength will be measured on a Materials Testing Systems instrument.

本研究的具体目的是确定 组织学上可确定的骨整合和 机械测试剪切界面强度的商业 纯的、可膨胀的光滑表面钛植入物。 因此，可以评估更多数量的样本 机械地，而不是从组织学上研究每一个，因此， 降低成本。 可膨胀的骨内植入物发挥有利的 压缩应力提供了一个环境， 骨生长到假体上。 骨置换扩张 对技术敏感步骤的需要，例如线程和 当没有精确地粘附时可能导致失效的攻丝。 长期目标是证明可扩张植入物 施加最佳的应用压缩水平， 骨整合的预后，从而提高 完全骨性愈合，缩短愈合时间， 完全骨整合。 这将提供更大 成功的功能性植入物的可预测性。 直径均匀增加的椭圆形植入物 当它们被扩张时，通过外科手术植入 家兔 相同配置的对照植入物受到 相同的植入技术。 两个不同时间段 被选中检查愈合和骨质疏松的变化 可以抵抗随时间推移推出的界面。 骨建模将 对于具有3种不同内部应用的植入物， 负载、次优、优和超优。 的量 骨整合将通过选择的组织学检查直接评估。 样本和预测间接的相对水平的接口 实力 植入技术将遵循以下原则 我推荐P。 布兰马克 组织学样本将 脱钙并准备切片，然后在 光镜 将测量剪切界面强度 在材料测试系统仪器上。