DETECTION OF BONE VIBRATION BY SQUID DEVICE

SQUID装置检测骨振动

• 批准号: 3431601
• 负责人: SUBRATA SAHA
• 金额: $ 3.14万
• 依托单位: LOUISIANA STATE UNIV HSC SHREVEPORT
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-08-01 至 1991-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3431601
• 关键词: bone density; clinical biomedical equipment; diagnosis quality /standard; electrophysiology; human subject; magnetic field; mathematical model; mechanical stress; musculoskeletal disorder diagnosis; noninvasive diagnosis; osteoporosis

Development of non-invasive methods for quantitating the bone mass is important in the diagnosis and treatment of many skeletal diseases, particularly for osteoporosis. The objective of this study will be to determine if a SQUID (superconducting quantum interference device) device can be used to detect the magnetic field produced by the flow of stress generated potential in a long bone. Vibration or stress wave propagation of human long bones will be monitored by bonded strain gages and by a SQUID. Subsequently the load carrying capacity of the bones will be determined by mechanical testing. Cortical thickness of the bones will be measured and samples for the bone will be ashed to determine the mineral content. Measured magnetic parameters such as amplitude, attenuation and scattering will be correlated with the measured cortical thickness, bone density, bone mineral content, and the load carrying capacity of each bone. Similarly, correlation coefficients will be calculated between the measured parameters with the radiographic density. An analysis of these data will show the relative accuracy of the SQUID measurements as a non- invasive method of the assessment of the degree of osteoporosis in patients. The outcome of this study may prove valuable in the treatment of osteoporosis, if we can show that small changes in the bone density and cortical thickness can be measured accurately by SQUIDs. The effect of different treatment modalities can then be evaluated on an objective basis. The advantage of SQUID technique will be that the patients will not be exposed to radiation. Similarly, the SQUID may be moved along the length and circumference of a limb and the output can then be plotted as a new method of computed tomography for our skeletal system. A mathematical model of stress wave propagation in long bone will also be developed, and from this model, the magnetic fields due to a known stress pattern in a long bone will be calculated. This data will be utilized to verify our SQUID measurements and also to predict changes in the magnetic field due to changes in the cortical thickness and bone density.

骨组织非侵入性定量方法的研究进展 肿块在许多骨骼疾病的诊断和治疗中很重要 疾病，尤其是骨质疏松症。这项研究的目的是 将确定一个鱿鱼(超导量子 干扰装置)装置可用于检测磁感应强度 流动场产生的应力在长时间内产生势能 骨头。 人体长骨的振动或应力波传播 由粘合应变片和一条鱿鱼监测。随后 骨骼的承载能力将由以下因素决定 机械测试。骨骼的皮质厚度将是 骨头的测量和样本将被灰化以确定 矿物质含量。 测量的磁参数，如幅度、衰减 散射将与测量的大脑皮层相关 厚度、骨密度、骨矿含量和负荷 每根骨头的承载能力。类似地，相关性 将计算测量参数之间的系数 随着射线密度的增加。对这些数据的分析将表明 SQUID测量的相对精度作为非 骨质疏松症程度的侵入性评估方法 在病人身上。 这项研究的结果可能被证明是有价值的治疗 骨质疏松症，如果我们能显示出骨骼的微小变化 密度和皮质厚度可以通过以下方法精确测量 鱿鱼。然后，不同治疗方式的效果可以 在客观的基础上进行评估。鱿鱼的优势 技术将是患者不会接触到 辐射。类似地，鱿鱼可以沿长度移动 和肢体的周长，然后输出可以绘制为 一种新的骨骼系统计算机断层扫描方法。 长骨中应力波传播的数学模型 也将开发出，从这个模型，磁场 由于已知的应力模式在长骨中会被计算出来。 这些数据将被用来验证我们的SQUID测量和 还可以预测由于磁场变化而引起的磁场变化 皮质厚度和骨密度。