THIRTEENTH INTERNATIONAL HERPESVIRUS WORKSHOP

该提案要求提供资金，使科学家，特别是年轻的科学家， 第十三届国际疱疹病毒研讨会 1988年8月7日至13日在加利福尼亚州欧文市的加州大学进行。 本次研讨会的力量和重要性取决于支持和 主要研究人员、有前途的年轻人 调查人员和学生的培训，和广泛的基础 国际出席。 与会者包括以下领域的专家： 分子生物学，免疫学，肿瘤，发病机制，潜伏期， 流行病学、临床研究和生物医学方法 治疗和预防。 许多演讲将涉及 与人类疱疹病毒，这导致了广泛的， 疾病综合征 这些包括肿瘤，如 鼻咽癌、伯基特淋巴瘤和B细胞 瘤形成，均与EB病毒相关;以及感染性 疾病如皮肤和眼睛溃疡（HSV-1）、生殖器损伤 （HSV-2）、传染性单核细胞增多症（EBV）和水痘， 带状疱疹（VZV）。 在新生儿中，先天性CMV感染是一种 智力迟钝和出生缺陷的主要原因。所有 人类疱疹病毒可终生存在， 治疗和管理中的问题 免疫抑制。 癌症患者，器官移植 接受者和艾滋病患者特别容易受到 潜伏的HSV、EBV、CMV和VZV的再活化，导致 发病率和死亡率增加。 自身免疫性疾病 （类风湿性关节炎）和神经系统疾病（亚急性骨髓炎， 视神经病变）也被报道与 疱疹病毒 动物疱疹病毒具有显著的经济效益， 对家禽（马立克氏病病毒）、猪 （伪狂犬病病毒）和乳制品（牛鼻气管炎病毒） 工业和马疱疹病毒造成重大损失， 养马人 此外，与猿猴相关的肿瘤 以松鼠猴疱疹病毒和马立克氏病病毒为模型 疱疹病毒基础研究系统 致瘤性 研讨会的组织者是爱德华·K博士。瓦格纳，部门的 分子生物学和生物化学，和博士罗珊M。桑德里- 戈尔丁省微生物学和分子遗传学，大学 来自加州欧文市 主题包括：基因调控，潜伏期 和发病机制，免疫学，肿瘤，复制， 糖蛋白和结构蛋白、酶和非结构蛋白 蛋白质、顺式元件和基序以及生物医学方法。

This proposal requests funds to enable scientists, especially young investigators, to attend 13th International Herpesvirus Workshop at the University of California, Irvine, CA, August 7-13, 1988. The strength and importance of this workshop rest on support and participation of leading researchers, promising young investigators and students in training, and broad-based international attendance. Participants include specialists in molecular biology, immunology, neoplasia, pathogenesis, latency, epidemiology, clinical investigations, and biomedical approaches to treatment and prevention. Many of the presentations will deal with the human herpesviruses, which cause a wide range of disease syndromes. These include neoplasia, such as nasopharyngeal carcinoma, Burkitt's lymphoma, and B-cell neoplasia, all associated with Epstein-Barr virus; and infectious diseases such as skin and eye ulcerations (HSV-1), genital lesions (HSV-2), infectious mononucleosis (EBV), and chicken pox and shingles (VZV). In neonates, congenital CMV infections are a major cause of mental retardation and birth defects. All of the human herpesviruses persist for life and therefore pose significant problems in the treatment and management of the immunologically suppressed. Cancer patients, organ transplant recipients, and AIDS patients are particularly susceptible to reactivation of latent HSV, EBV, CMV, and VZV, resulting in increased morbidity and mortality. Autoimmune diseases (rheumatoid arthritis) and neurological diseases (subacute-myelo- opticoneuropathy) have also been reported to be linked to herpesviruses. Animal herpesviruses have significant economic importance to the poultry (Marek's Disease virus), swine (Pseudorabies virus), and dairy (bovine rhinotracheitis virus) industries and the equine herpesviruses cause significant losses to horse breeders. In addition, neoplasia associated with simian herpesvirus saimiri and Marek's disease virus serve as model systems for studying the underlying basis of herpesvirus oncogenicity. The Workshop organizers are Dr. Edward K. Wagner, Dept. of Molecular Biology and Biochemistry, and Dr. Rozanne M. Sandri- Goldin, Dept. of Microbiology and Molecular Genetics, University of California, Irvine. The topics include: gene regulation, latency and pathogenesis, immunology, neoplasia, replication, glycoproteins and structural proteins, enzymes and non-structural proteins, cis elements and motifs, and biomedical approaches.