CONFERENCE ON NEWLY DESCRIBED KERATINOCYTE FUNCTIONS

直到十年前，表皮生物学的研究才受到关注 主要与结构蛋白、屏障形成和 角质形成细胞的再生能力 结构完好无损。最近的实验数据显示， 表皮是一种非常多功能的器官。此外，通过 它的质量，丰富的血管和它与 环境从理论上讲，表皮处于独特的位置 向生物体的其他部分提供化学信号。这个 角质形成细胞是作为来源出现的表皮细胞， 有时，许多新描述的目标 功能。我们认为这次会议对以下方面来说是及时的 原因：有关以下方面的数据正在快速增长 角质形成细胞的新生物活性。这些数据已经被 被大多数调查人员狭隘地看待，但可以被赋予一个新的 如果从更广阔的角度来看，这是一种光明。建议数 会议将把调查人员与共同的 关注技术、方法论和生物学 意义。不同的调查小组分别 努力解决有关意义和作用的问题 对他们来说是特定兴趣的“活动”。带着这些 调查人员的共同努力将促进对将军的认可 原则和方法可以促进个人 努力激发人们对这些话题更广泛的兴趣。这个 我们提议的会议将聚焦于角质形成细胞及其 新描述的活动。这将首先通过一个 已知的生化和生理学研究进展 这些可溶性产物的特性和代谢活性 角质形成细胞。在适当的情况下，每个角质形成细胞产品 或活动将与区域讨论a)其在当地的角色 动态平衡，b)对其他器官系统或细胞的影响，以及c) 与同类产品的结构和功能关系或 来自器官系统的活动。拟议的会议将是 由纽约科学院赞助，应 吸引代表广泛领域的参与者和观众 兴趣。我们预计这次会议会吸引更多的人。 生物学家、蛋白质化学家、免疫学家、内分泌学家， 皮肤生物学家、临床皮肤科医生和博德 工业的组成部分。这些新描述的活动 角质形成细胞对新鲜度的获取有重要意义 对许多皮肤病的洞察力，可能会提出新的 治疗方法，不仅是皮肤病，而且是 系统性疾病。

Until ten years ago research in epidermal biology was concerned mainly with structural proteins, barrier formation, and the regenerative capacity of the Keratinocytes that kept the structure intact. More recent experimental data reveal the epidermis as an extraordinarily versatile organ. Moreover, by virtue of its mass, its rich vasculature and its contact with the environment the epidermis is theoretically in a unique position to provide chemical signals to the rest of the organism. The keratinocyte is the epidermal cell which has emerged as a source, and sometimes the target, of many of these newly described functions. We think this conference is timely for the following reasons: there is a rapidly increasing body of data concerning novel biological activities of keratinocytes. These data have been narrowly viewed by most investigators but could be cast in a new light if seen from a broader prospective. The proposed conference would bring together investigators with common concerns about technique, methodology and biological significance. Different groups of investigators individually grapple with questions dealing with the significance and function of "activities" specific interest to them. Bringing these investigators together would foster recognition of general principles and approaches that could facilitate the individual's work and stimulate a broader base of interest in these topics. The conference we propose will focus on the keratinocyte and its newly described activities. This will be accomplished first by a critical review of the known biochemical and physiological characteristics of these soluble products and metabolic activities of the keratinocyte. When appropriate, each keratinocyte product or activity will be discussed with regare to a) its role in local homeostasis, b) its effects on other organ systems or cells and c) its structural and functional relationship to similar products or activities from organ systems. The proposed conference will be sponsored by the New York Academy of Sciences and should attract participants and an audience representing a wide range of interests. We anticipate that the meeting should attract cell biologists, protein chemists, immunologists, endocrinologists, cutaneous biologists, clinical dermatologists and broad components of industry. These newly described activities of keratinocytes have significant implications for gaining fresh insights into many cutaneous diseases and may suggest new approaches to therapy, not only of cutaneous diseases but also systemic disease.