ANTERIOR TEMPORAL LOBECTOMY: COMPARISON OF TWO SURGICAL

前颞叶切除术：两种手术的比较

• 批准号: 3415302
• 负责人: ALLEN R WYLER
• 金额: $ 21.1万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-06-01 至 1996-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3415302
• 关键词: anticonvulsants; clinical depression; clinical trials; electrocorticography; electroencephalography; hippocampus; human subject; lateral olfactory area; longitudinal human study; magnetic resonance imaging; neuropsychological tests; neurosurgery; partial seizure; postoperative state; preoperative state; psychiatric patient care; psychosocial rehabilitation; social adjustment; temporal lobe /cortex disorder; vocational rehabilitation; young adult human (21-34)

This grant proposes a prospective longitudinal study of the seizure, psychiatric, neuropsychological, and vocational outcome of anterior temporal lobectomy (ATL) done for treatment of complex partial seizures of temporal lobe origin. ATL will be done by one surgical team but the patients will be randomized into two surgical groups. One patient group will have ATL done by a standard "en bloc" resection. The other patient groups will have complex partial seizures with ictal onset from mesial temporal structures and will not have a causal structural lesion (i.e., tumor or AVM) documented by MRI scan. The outcome of study will: (1) help clarify the role of hippocampus in nonlesional temporal lobe epilepsy, and (2) help clarify the which of several methods of ATL produce the best seizure outcome with minimal psychological and psychiatric impairment to patients. This proposal apples directly to the conclusion of the recent NIH consensus conference of Epilepsy Surgery.

这项拨款提议对癫痫发作进行前瞻性纵向研究， 精神、神经心理和职业结局 颞叶切除术（ATL）治疗复杂部分性癫痫发作 颞叶起源 ATL将由一个手术团队完成，但 将患者随机分为两个手术组。 一个患者组 将通过标准的“整块”切除术完成ATL。 另一例患者 组将有复杂的部分性癫痫发作，发作从近中 并且不会具有因果结构损伤（即， 肿瘤或AVM）。 研究结果将：（1）有助于 阐明海马在非病灶性颞叶癫痫中的作用， (2)帮助澄清ATL的几种方法中哪一种产生的效果最好 癫痫发作结局，心理和精神损害最小， 患者 这一建议直接符合最近的结论。 美国国立卫生研究院癫痫外科共识会议。