TIME RESOLVED SPECTROSCOPY OF HEMOGLOBIN IN BRAIN

大脑中血红蛋白的时间分辨光谱

• 批准号: 3413608
• 负责人: BRITTON CHANCE
• 金额: $ 14.5万
• 依托单位: UNIVERSITY CITY SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-04-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3413608
• 关键词: biomedical equipment development; brain disorder diagnosis; brain imaging /visualization /scanning; cats; cerebral ischemia /hypoxia; clinical biomedical equipment; disease /disorder model; dogs; hemoglobin; human subject; intracranial hematoma; lasers; mathematical model; methemoglobin; newborn human (0-6 weeks); noninvasive diagnosis; optics; phantom model; respiratory oxygenation; spectrometry; visible light

The possibility of quantitative measurements of deoxyhemoglobin concentrations in the neonate and adult brain depends upon picosecond pulse of phase modulation spectroscopy that determines the optical path traveled by photons exiting from the brain. Algorithms, based upon a program of milk and animal models, will be developed to permit localization of pathological states due to brain bleeding, i.e., hematomas or aneurysms. Thus, the possibility of on-radioactive, non-magnetic, non-confining studies based upon innocuous low-powered deposition near red illumination on the surface of the head is the general goal of these studies. These developments can lead to a new technology of quantitation and localization of normal and pathological levels of deoxyhemoglobin in the human brain. It is conceived that this instrument has clinical applications and safety aspects that would allow it to be used wherever needed in research and clinical studies.

脱氧血红蛋白定量检测的可能性 新生儿和成人大脑中的浓度取决于 皮秒脉冲的相位调制光谱，确定了 从大脑发出的光子所经过的光路。 基于牛奶和动物模型程序的算法将 被开发为允许定位由于以下原因的病理状态 脑出血，即血肿或动脉瘤。因此， 非放射性、非磁性、非禁闭研究的可能性 基于红光附近无毒的低功率沉积 头的表面是这些研究的总体目标。 这些发展可以导致一种新的定量和 正常和病理脱氧血红蛋白水平的定位 在人脑中。据认为，这种仪器具有 临床应用和安全性方面，使其能够 在研究和临床研究中需要的地方使用。