Novel strategies for the treatment of alcohol dependance

治疗酒精依赖的新策略

• 批准号: nhmrc : 402862
• 负责人: A/Pr Kirsten Morley
• 金额: $ 19.38万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-strategies-treatment-alcohol-dependance/114763
• 关键词: Novel; strategies; treatment; alcohol; dependance

The proposed project is designed to extend my current project and improve the treatment of alcohol dependence by addressing three barriers to successful treatment. Firstly, a novel, integrated, stepped-care treatment for alcohol dependence and comorbid anxiety or depression will be examined in a randomised controlled trial. Secondly, the relationship between sleep disturbances, relapse and treatment retention and outcomes will be characterised. Thirdly, genetic predictors to the treatment of the anti-craving medications, acamprosate and naltrexone will be investigated. The first two aims will utilise subjects recruited across three sites in Sydney while the third aim will involve analyses of blood samples and clinical data from my current project

拟议的项目旨在扩展我当前的项目，并通过解决成功治疗的三个障碍来改善酒精依赖的治疗。首先，将在一项随机对照试验中检验一种针对酒精依赖和共病焦虑或抑郁的新颖、综合、阶梯式护理治疗方法。其次，将描述睡眠障碍、复发和治疗保留与结果之间的关系。第三，将研究抗渴望药物阿坎酸和纳曲酮治疗的遗传预测因素。前两个目标将利用在悉尼三个地点招募的受试者，而第三个目标将涉及对我当前项目的血液样本和临床数据进行分析