Defining the clinical role of topiramate in the treatment of alcohol dependence in Australia

定义托吡酯在澳大利亚治疗酒精依赖中的临床作用

• 批准号: nhmrc : GNT1104288
• 负责人: A/Pr Kirsten Morley
• 金额: $ 71.88万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-clinical-role-dependence-australia/1346347
• 关键词: Defining; clinical; role; topiramate; treatment

We urgently require new strategies for the treatment of alcohol dependence. The effectiveness of currently approved alcohol medications is limited. Emerging data suggests that topiramate has robust effectiveness and that better medicine selection is possible for patients based on their genotype. We propose to conduct a double-blind randomised controlled trial to examine the clinical and cost effectiveness of topiramate using a genetically based personalised approach.

我们迫切需要治疗酒精依赖的新策略。目前批准的酒精药物的有效性是有限的。新出现的数据表明，托吡酯具有强大的有效性，并且可以根据患者的基因型选择更好的药物。我们建议进行一项双盲随机对照试验，采用基于基因的个体化方法来检查托吡酯的临床和成本效益。