Viral Persistence and Pathogenesis

项目摘要 病毒已经进化出一系列机制来避免被宿主检测和/或消除 防御和建立持续感染，不仅确保人类群体的生存，而且可以 也参与了发病机制。虽然我们已经开发出有效的抗病毒药物和疫苗来对抗一些 重要的病毒，全世界病毒疾病的威胁仍然存在，主要是由于抗原性的漂移和转移，药物 抗药性突变体、新出现的传染病病原体，以及重要的持续性或潜伏性感染。复杂性 而病毒利用的持久性和致病机制的多样性对 开发有效的疫苗和以化学或免疫为基础的病毒疾病治疗。致信地址 这些复杂的问题，至关重要的是要了解病毒持续存在和 发病机制，在分子水平上。因此，仍然迫切需要培训新一代的 具有跨学科经验和专业知识的独立调查人员，以处理 病毒的持久性和致病机制。培训方案的一个目标是，并将继续是 招聘相关学科(生物化学、生物化学、生物化学)的本科生和新近毕业的博士 科学、细胞和分子生物学等)，深入研究病毒持续和 发病机制。该培训计划汇集了越来越多的致力于 微生物学和分子遗传学系的病毒研究和翻译研究 该大学儿科、癌症病毒学项目和疫苗研究中心 匹兹堡医学院和公共卫生研究生院。病毒的持久力和 发病机制(VPP)培训计划为协调跨学科研究提供了独特的机会 在微生物学和免疫学(PMI)方案框架内培训博士前实习生 VPP教员实验室内的博士后实习生，通过专业课程进行额外培训 提供服务、专门的研究研讨会、务虚会和参加国家科学会议。重要的是 VPP计划的独特之处在于它利用了来自不同病毒的持久性和致病机制方面的概念 系统，其目的是教育受训者了解各种机制，但也使 他们研究的共同主题。每年支持4名博士后和2名博士后实习生 已请求。VPP计划仍然致力于增加受训人员的多样性，以提供 对负责任的研究行为进行培训，并为受训者提供职业指导。

Project Summary Viruses have evolved a vast array of mechanisms to avoid detection and/or elimination by host defenses and to establish persistent infections that not only ensures survival in the human population, but can also contribute to pathogenesis. While we have developed effective antiviral drugs and vaccines against some important viruses, the threat of viral diseases worldwide remains, largely due to antigenic drift and shift, drug resistant mutants, emerging infectious agents, and importantly persistent or latent infections. The complexity and diversity of persistence and pathogenesis mechanisms utilized by viruses pose major challenges to the development of effective vaccines and chemical or immune-based treatments of virus diseases. To address these complex problems, it is essential to understand the mechanisms underlying viral persistence and pathogenesis, at the molecular level. Thus, there continues to be an urgent need to train a new generation of independent investigators with the interdisciplinary experience and expertise to address the complex issues of viral persistence and pathogenesis. A goal of the training program has been, and will continue to be, the recruitment of undergraduates and recent Ph.D. graduates in related disciplines (biochemistry, biological sciences, cellular and molecular biology, etc) into advanced studies in mechanisms of viral persistence and pathogenesis. The training program brings together the expanding number of basic science faculty devoted to the study of viruses and translational research in the Department of Microbiology and Molecular Genetics, the Department of Pediatrics, the Cancer Virology Program, and the Center for Vaccine Research at the University of Pittsburgh School of Medicine, and the Graduate School of Public Health. The Viral Persistence and Pathogenesis (VPP) training program offers a unique opportunity for the coordinated interdisciplinary research training of predoctoral trainees within the structure of the Program in Microbiology and Immunology (PMI) and postdoctoral trainees within the laboratories of the VPP faculty, with additional training via specialized course offerings, dedicated research seminars, retreats, and participation in national scientific meetings. Importantly, the VPP program is unique in that it leverages concepts in persistence and pathogenesis from diverse viral systems with the goal of educating trainees of the diversity of mechanisms, but also enabling the utilization of common themes for their research. Support for 4 predoctoral and 2 postdoctoral trainees per year is requested. The VPP program remains committed to the need to increase diversity in trainees, to provide training in the responsible conduct of research, and to provide career guidance for trainees.