MRI Guided Robotic Cardiac Surgery
MRI Guided Robotic Cardiac Surgery
批准号:
7735010
负责人:
Keith A Horvath
金额:
$36.6万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
AnatomyAnimalsBioprosthesis deviceBlood flowCardiac Surgery proceduresCardiopulmonary BypassCompatibleCoronary arteryFamily suidaeFunctional ImagingHeartImageImageryImplantInterventionInvasiveLeft ventricular structureMagnetic Resonance ImagingModificationMyocardialOperative Surgical ProceduresPatientsPerfusionPhasePlacementProceduresProsthesisPumpRoboticsScanningSeriesSignal TransductionSurgeonSurgical incisionsSus scrofaTechniquesTimeTraumaTrocarsUpper armaortic valveimplantationvisual feedback
中文摘要
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英文摘要
The principal limitations of percutaneous techniques to replace the aortic valve principal are detailed visualization and durable prostheses. This study investigated the use of real-time magnetic resonance imaging to provide precise anatomic detail and visual feedback to implant a proven bioprosthesis.
Via a minimally invasive approach using real-time MRI guidance 22 pigs underwent off-pump aortic valve replacement. MR imaging was used to precisely identify critical anatomic landmarks. Additional intraoperative perfusion, flow velocity and functional imaging were used to confirm adequacy of placement and function of the valve.
Under real-time MR imaging, multiple oblique planes were prescribed. Enhanced by the use of an active (i.e. MR signal receiving loopless antennae) marker wire, this imaging allowed correct placement and orientation of the prosthetic valve. Via a transapical approach a series of bioprosthetic aortic valves (21-25mm) were inserted. The time to implantation after the placement of the trocar to deployment of the valve was less than ninety seconds (77 + 12). In addition to anatomic confirmation of adequate placement of the prosthetic valve in relation to the aortic annulus and the coronary arteries, functional confirmation of the valve and left ventricle was also obtained with MR imaging. Intraoperative first pass perfusion scanning documented adequacy of myocardial blood flow after valve placement. Phase velocity confirmed adequate opening of the prosthetic valve leaflets and lack of valvular or paravalvular regurgitation.
Real-time MR imaging provides excellent anatomic detail and intraoperative assessment that permits placement of durable valve prostheses on the beating heart without the limitations of percutaneous approaches.
We are presently allowing animals to recover from these procedures and following them long term to assess the durability of the technique. Additionally we have started to employ MR compatible robotic arms to extend the surgeons' capability.
期刊论文(8)
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Transapical sutureless aortic valve implantation under magnetic resonance imaging guidance: Acute and short-term results.
磁共振成像引导下经心尖无缝合主动脉瓣植入:急性和短期结果。
DOI:
10.1016/j.jtcvs.2014.10.101
发表时间:
2015
期刊:
The Journal of thoracic and cardiovascular surgery
影响因子:
--
作者:
[Horvath,KeithA, Mazilu,Dumitru, Cai,Junfeng, Kindzelski,Bogdan, Li,Ming]
通讯作者:
Li,Ming
Robotic system for transapical aortic valve replacement with MRI guidance.
MRI 引导下经心尖主动脉瓣置换的机器人系统。
DOI:
10.1007/978-3-540-85990-1_57
发表时间:
2008
期刊:
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
影响因子:
--
作者:
[Li,Ming, Mazilu,Dumitru, Horvath,KeithA]
通讯作者:
Horvath,KeithA
DOI:
10.1016/j.jtcvs.2009.08.005
发表时间:
2010-02
期刊:
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
影响因子:
6
作者:
[Horvath, Keith A., Mazilu, Dumitru, Guttman, Michael, Zetts, Arthur, Hunt, Timothy, Li, Ming]
通讯作者:
Li, Ming
DOI:
10.1016/j.jtcvs.2015.11.024
发表时间:
2016-05
期刊:
The Journal of thoracic and cardiovascular surgery
影响因子:
--
作者:
[Miller JG, Li M, Mazilu D, Hunt T, Horvath KA]
通讯作者:
Horvath KA
DOI:
10.1109/robot.2009.5152541
发表时间:
2009-07-06
期刊:
IEEE International Conference on Robotics and Automation : ICRA : [proceedings]. IEEE International Conference on Robotics and Automation
影响因子:
--
作者:
[Kapoor A, Wood B, Mazilu D, Horvath KA, Li M]
通讯作者:
Li M
共 7 条
Laser Induced Myocardial Angiogenesis
-
批准号:6537812
-
项目类别:
-
资助金额:$17.69万
-
财政年份:2001
-
负责人:Keith A Horvath
-
依托单位:
Laser Induced Myocardial Angiogenesis
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批准号:6749558
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项目类别:
-
资助金额:$16.34万
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财政年份:2001
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负责人:Keith A Horvath
-
依托单位:
Laser Induced Myocardial Angiogenesis
-
批准号:6370794
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项目类别:
-
资助金额:$17.89万
-
财政年份:2001
-
负责人:Keith A Horvath
-
依托单位:
Laser Induced Myocardial Angiogenesis
-
批准号:6638647
-
项目类别:
-
资助金额:$16.45万
-
财政年份:2001
-
负责人:Keith A Horvath
-
依托单位:
Myocardial Cellular Stimulation of Angiogenesis
-
批准号:7321782
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Keith A Horvath
-
依托单位:
Cardiac Xenotransplantation
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批准号:7735009
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项目类别:
-
资助金额:$37.71万
-
财政年份:--
-
负责人:Keith A Horvath
-
依托单位:
Cardiac Xenotransplantation
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批准号:7594429
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项目类别:
-
资助金额:$69.83万
-
财政年份:--
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负责人:Keith A Horvath
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依托单位:
Myocardial Cellular Stimulation of Angiogenesis
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批准号:7735008
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项目类别:
-
资助金额:$36.6万
-
财政年份:--
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负责人:Keith A Horvath
-
依托单位:
Myocardial Cellular Stimulation of Angiogenesis
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批准号:7594428
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项目类别:
-
资助金额:$67.78万
-
财政年份:--
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负责人:Keith A Horvath
-
依托单位:
Cardiac Xenotransplantation
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批准号:7321783
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Keith A Horvath
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依托单位:
MRI Guided Robotic Cardiac Surgery
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批准号:7594430
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项目类别:
-
资助金额:$67.78万
-
财政年份:--
-
负责人:Keith A Horvath
-
依托单位:
MRI Guided Robotic Cardiac Surgery
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批准号:7321785
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:Keith A Horvath
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依托单位:
海外基金