Laser Induced Myocardial Angiogenesis

激光诱导心肌血管生成

基本信息

  • 批准号:
    6749558
  • 负责人:
  • 金额:
    $ 16.34万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2001
  • 资助国家:
    美国
  • 起止时间:
    2001-07-15 至 2005-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (Provided by Applicant): There are an increasing number of patients with disabling angina as a result ot end-stage coronary artery disease. Transmyocardial laser revascularization (TMR) was developed to provide an option for these patients. who are not amenable to conventional methods of revascularization. Clinically, TMR successfully reduces anginal symptoms and improves the quality of the patient's life. The exact mechanism whereby TMR achieves these results is unclear. The objective of this study is to investigate the importance of angiogenesis as a mechanism of TMR. Specifically to determine if there is an upregulation of angiogenic growth factors after TMR. With more endogenous production of angiogens, new blood vessels should develop, perfusion increase and function improve. The potential synergistic response to the addition of exogenous angiogenic growth factors in combination with TMR will be examined. Variations in the response due to different wavelengths of laser light and differences in tissue penetration of this light will be studied. An established animal model of chronic myocardial ischemia will be employed. The angiogenic response will be assessed: 1.) on a molecular basis by demonstrating an increase in the mRNA for bFGF and VEGF; 2.) histologically by an increase in new blood vessels. Perfusion changes will be assessed by colored microspheres and perfusion MRI. Functional changes will be monitored by stress echocardiography and cine MRI. Further enhancement of the angiogenic response will be achieved by the intramyocardial addition of bFGF protein and by VEGF delivered via an adenoviral mediated gene transfer. Finally the differences in TMR by infrared light (carbon dioxide) versus ultraviolet light (excimer) will be assessed. While the clinical results are encouraging, better understanding of the mechanisms of TMR will lead to better treatment for these patients.
描述(由申请人提供):越来越多的患者由于终末期冠状动脉疾病而导致致残性心绞痛。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
What is the optimal channel density for transmyocardial laser revascularization?
  • DOI:
    10.1016/j.athoracsur.2004.04.047
  • 发表时间:
    2004-10
  • 期刊:
  • 影响因子:
    0
  • 作者:
    S. Mouli;J. Fronza;R. Greene;Emmanuel Robert;K. Horvath
  • 通讯作者:
    S. Mouli;J. Fronza;R. Greene;Emmanuel Robert;K. Horvath
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Keith A Horvath其他文献

Keith A Horvath的其他文献

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{{ truncateString('Keith A Horvath', 18)}}的其他基金

Laser Induced Myocardial Angiogenesis
激光诱导心肌血管生成
  • 批准号:
    6537812
  • 财政年份:
    2001
  • 资助金额:
    $ 16.34万
  • 项目类别:
Laser Induced Myocardial Angiogenesis
激光诱导心肌血管生成
  • 批准号:
    6370794
  • 财政年份:
    2001
  • 资助金额:
    $ 16.34万
  • 项目类别:
Laser Induced Myocardial Angiogenesis
激光诱导心肌血管生成
  • 批准号:
    6638647
  • 财政年份:
    2001
  • 资助金额:
    $ 16.34万
  • 项目类别:
Myocardial Cellular Stimulation of Angiogenesis
血管生成的心肌细胞刺激
  • 批准号:
    7321782
  • 财政年份:
  • 资助金额:
    $ 16.34万
  • 项目类别:
Cardiac Xenotransplantation
心脏异种移植
  • 批准号:
    7735009
  • 财政年份:
  • 资助金额:
    $ 16.34万
  • 项目类别:
Cardiac Xenotransplantation
心脏异种移植
  • 批准号:
    7594429
  • 财政年份:
  • 资助金额:
    $ 16.34万
  • 项目类别:
Myocardial Cellular Stimulation of Angiogenesis
血管生成的心肌细胞刺激
  • 批准号:
    7735008
  • 财政年份:
  • 资助金额:
    $ 16.34万
  • 项目类别:
Myocardial Cellular Stimulation of Angiogenesis
血管生成的心肌细胞刺激
  • 批准号:
    7594428
  • 财政年份:
  • 资助金额:
    $ 16.34万
  • 项目类别:
MRI Guided Robotic Cardiac Surgery
MRI 引导机器人心脏手术
  • 批准号:
    7735010
  • 财政年份:
  • 资助金额:
    $ 16.34万
  • 项目类别:
Cardiac Xenotransplantation
心脏异种移植
  • 批准号:
    7321783
  • 财政年份:
  • 资助金额:
    $ 16.34万
  • 项目类别:
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