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Longitudinal Investigation of Fertility and the Environment

生育力与环境的纵向调查

基本信息

批准号：
7734783
负责人：
germaine louis
金额：
$ 20.8万
依托单位：
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7734783
关键词：
Adult Adverse effects Alcohols Birth Blood Cigarette Clinical Cotinine Count Couples Data Development End Point Ensure Environment Environmental Exposure Environmental Impact Environmental Pollution Environmental Risk Factor Epidemiologic Studies Female Fertility Geographic Locations Home environment Human Hydrocortisone Infant Infertility Interview Investigation Life Life Style Literature Longitudinal Studies Measurement Measures Mediating Metals Mission Monitor Morphology National Institute of Child Health and Human Development Outcome Patient currently pregnant Peer Review Phytoestrogens Polychlorinated Biphenyls Pregnancy Pregnancy loss Process Psyche structure Purpose Recruitment Activity Reproduction Research Saliva Sampling Seminal fluid Serum Stress Time Urine Woman disability environmental chemical interest male men organochlorine pesticide phenyl ether reproductive size sperm cell

项目摘要

The purpose of the LIFE Study is to assess the impact of environmental factors, broadly defined to include lifestyle factors, on human reproduction and development. The LIFE Study is consistent with the mission of the National Institute of Child Health and Human Development that includes conducting basic, clinical and epidemiologic research focusing on factors and processes associated with human reproduction and development thereby, ensuring the birth of healthy infants capable of reaching full adult potential unimpaired by physical or mental disabilities. This study will assess the relation between select environmental factors and human fecundity and fertility. This research proposes to recruit and retain 800 couples interested in becoming pregnant and willing to participate in a longitudinal study. Couples will be selected from geographic regions that were chosen from peer reviewed competitive proposals. Fecundity will be measured by the time required for the couples to achieve pregnancy, while fertility will be measured by the ability of couples to have a live born infant. Infertility will be recognized for couples unable to conceive within 12 months of trying. The studys primary environmental exposures include: organochlorine pesticides; polychlorinated biphenyls; polybrominated diphenyl ethers; metals; perfluorinated compounds; cotinine; and phytoestrogens. A growing body of literature suggests these compounds may exert adverse effects on human reproduction and development; however, definitive data are lacking especially for sensitive endpoints. Couples will participate in a 25-minute baseline interview and be instructed in the use of home fertility monitors and pregnancy kits for counting the time required for pregnancy and detecting pregnancy. Blood and urine samples will be collected at baseline from both partners of the couple for measurement of the environmental exposures. Two semen samples from male partners and two saliva samples from female partners also will be requested. Semen samples will be used to globally assess male fecundity as measured primarily by sperm concentration and morphology. Saliva samples will be used for the measurement of cortisol levels as a marker of stress among female partners so that the relation between environmental factors, stress and human reproduction can be assessed. The findings will provide valuable information regarding the effect of environmental contaminants on sensitive markers of human reproduction and development, filling critical data gaps. Moreover, these environmental exposures will be analyzed in the context of other lifestyle exposures such as use of cigarettes and alcohol, consistent with the manner in which human beings are exposed.

生命研究的目的是评估环境因素（广义上包括生活方式因素）对人类繁殖和发展的影响。 LIFE 研究与国家儿童健康和人类发展研究所的使命一致，包括开展基础、临床和流行病学研究，重点关注与人类生殖和发育相关的因素和过程，从而确保健康婴儿的出生能够充分发挥成年潜力，不受身体或精神残疾的影响。这项研究将评估特定环境因素与人类生育力和生育力之间的关系。这项研究计划招募并保留 800 对有兴趣怀孕并愿意参与纵向研究的夫妇。情侣将从经过同行评审的竞争性提案中选出的地理区域中选出。生育力将通过夫妇怀孕所需的时间来衡量，而生育力将通过夫妇生下活产婴儿的能力来衡量。尝试怀孕 12 个月内无法怀孕的夫妇将被诊断为不孕症。研究的主要环境暴露包括：有机氯农药；多氯联苯；多溴二苯醚；金属；全氟化合物；可替宁；和植物雌激素。越来越多的文献表明这些化合物可能对人类生殖和发育产生不利影响。然而，缺乏明确的数据，尤其是敏感终点的数据。夫妇将参加 25 分钟的基线访谈，并接受指导如何使用家庭生育监测仪和怀孕套件来计算怀孕所需的时间和检测怀孕。将从夫妇双方的基线处采集血液和尿液样本，以测量环境暴露情况。还需要男性伴侣的两份精液样本和女性伴侣的两份唾液样本。精液样本将用于全球评估男性的生育力，主要通过精子浓度和形态来测量。唾液样本将用于测量皮质醇水平，作为女性伴侣压力的标志，以便评估环境因素、压力和人类生殖之间的关系。这些发现将提供有关环境污染物对人类生殖和发育敏感标记的影响的宝贵信息，填补关键数据空白。此外，这些环境暴露将在其他生活方式暴露（例如吸烟和饮酒）的背景下进行分析，与人类暴露的方式一致。