Project 2 - Immunogenetic and Exposure Factors in Berylliosis

项目 2 - 铍中毒的免疫遗传学和暴露因素

• 批准号: 7714445
• 负责人: LISA A MAIER
• 金额: $ 47.45万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-11 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7714445
• 关键词: Arts; Beryllium; Biometry; Biostatistics Core; Clinical; Clinical Research; Collaborations; Complex; Consultations; Core Facility; Cost Savings; Data; Data Analyses; Databases; Development; Disease; Doctor of Philosophy; Ensure; Equipment; Exposure to; Familiarity; Genetic; Grant; Human Resources; Immunologic Factors; Immunologics; Industrial Health; Informatics; Instruction; Interview; Laboratories; Lead; Leadership; Maintenance; Methodology; Methods; Metric; Modeling; Monitor; Process; Public Health; Quantitative Genetics; Reporting; Research; Research Design; Research Personnel; Resources; Security; Services; Statistical Methods; Work; cohort; data acquisition; data management; data modeling; disorder risk; experience; genetic analysis; genetic association; genetic epidemiology; meetings; member; multidisciplinary; organizational structure; response; skills; statistics

The Biostatistics and Exposure Core will provide an integrated approach to all projects with regard to 1) study design, 2) biostatistical analysis, 3) data management and informatics, and 4) exposure assessment. By centralizing these activities, this multidisciplinary Core will boost the level of interaction among the projects and between projects and the Core. It will allow us to coordinate study design and data management issues, leading to a more coherent approach to exposure assessment and data analysis as well as significant cost savings. The Core Director (Fingeriin) and Co-Director, exposure assessment liaison (Martyny) will supervise a team experienced in conducting studies and coordinating multidisciplinary teams in clinical research. The team has the skill set required to manage complex issues of study design, epidemiology, genetics, quantitative methods, data management and exposure assessment. Interaction with Projects and Cores: The Biostatistics and Exposure Core will service all three projects. All projects will receive assistance with study design from the Core including consultation with project Pis on methodological issues, at the initiation of a study, and ongoing consultation as the study progresses. All three projects will also be served by the Core's biostatistical analysis responsibilities by: 1) meeting with Project Leaders to determine analysis needs, 2) conducting the analysis through the Core statistics team, Drs. Fingeriin and Strand and Ms. Silveira, for all three Projects, and directing the statistical analysis of genetic association studies for Project 2, and 3) assisting in the development of specialized models for data in Project 3. The Core's Data Management and Informatics responsibilities will extend to all three projects as well as the Administrative and Clinical Laboratory Cores including: 1) management of data acquisition and transfer, 2) development and maintenance of research databases, 3) ensuring data backup, storage, and security. The Exposure Assessment responsibilities of the Core will primarily serve Projects 2 and 3 including: 1) exposure interviews for new cohort members, 2) acquisition, analysis, and management of industrial hygiene monitoring data for NJH cohort employers, 3) collaboration with investigators responsible for other cohorts to develop consistent exposure assessment methods 4) development of uniform exposure metric across all cohorts to be used in this POI. The Biostatistics and Exposure Core will interact with the Administrative Core, as it provides the administrative and organizational structure to support this grant. This Core will receive direction from the Administrative, the Executive Committee, and Clinical Laboratory Cores at monthly meetings ofthe PI, Co-PI and Project Leaders, and provide reports on its activities as needed. RELEVANCE (See instructions): The reason why some workers develop sensitization or disease when exposed to beryllium while others do not, is likely related to genetic and exposure factors, acting in concert to determine disease risk. This core provides the biostatistical and exposure resources necessary to analyze the genetic, exposure, and immunological factors important for all three projects in this POI. These analyses and exposure assessments will clarify the immunologic and exposure-disease relationships, and will have public health implications in the understanding of this and other environmental diseases.

生物统计和暴露核心将为所有项目提供以下方面的综合方法：1) 研究设计，2) 生物统计分析，3) 数据管理和信息学，以及 4) 暴露评估。 通过集中这些活动，这个多学科核心将提高各学科之间的互动水平 项目之间以及项目与核心之间。它将允许我们协调研究设计和数据 管理问题，从而形成更加一致的暴露评估和数据分析方法 以及显着的成本节省。核心总监（Fingeriin）和暴露评估联络联席总监 （Martyny）将监督一支在开展研究和协调多学科团队方面经验丰富的团队 在临床研究中。该团队拥有管理研究设计复杂问题所需的技能， 流行病学、遗传学、定量方法、数据管理和暴露评估。相互作用 项目和核心：生物统计和暴露核心将为所有三个项目提供服务。所有项目 将获得核心的研究设计协助，包括与项目 Pis 进行咨询 研究开始时的方法学问题，以及研究进展过程中的持续咨询。全部 核心生物统计分析职责也将通过以下方式为三个项目提供服务： 1) 与 项目负责人确定分析需求，2) 通过核心统计团队进行分析， 博士。 Fingeriin 和 Strand 以及 Silveira 女士，负责所有三个项目，并指导统计分析 项目 2 和 3 的遗传关联研究，协助开发专门的数据模型 在项目 3 中。核心的数据管理和信息学职责将扩展到所有三个项目 以及管理和临床实验室核心，包括：1）数据采集和管理的管理 传输，2) 研究数据库的开发和维护，3) 确保数据备份、存储和 安全。核心的暴露评估职责将主要服务于项目 2 和 3 包括：1）对新群体成员进行接触访谈，2）获取、分析和管理 NJH 队列雇主的工业卫生监测数据，3) 与负责调查人员的合作 让其他群体制定一致的暴露评估方法 4) 统一暴露的制定 在此 POI 中使用的所有群组的指标。生物统计和暴露核心将与 行政核心，因为它提供了支持这笔赠款的行政和组织结构。这 核心将接受行政、执行委员会和临床实验室核心的指导 参加 PI、Co-PI 和项目负责人的月度会议，并根据需要提供有关其活动的报告。 相关性（参见说明）： 为什么有些工人在接触铍时会出现过敏或疾病，而另一些工人则会出现过敏或疾病 不是，很可能与遗传和暴露因素有关，共同作用来确定疾病风险。这个核心 提供分析遗传、暴露和风险所需的生物统计和暴露资源 免疫因素对该 POI 中的所有三个项目都很重要。这些分析和暴露评估 将澄清免疫学和暴露-疾病关系，并将对以下领域的公共卫生产生影响 对这种疾病和其他环境疾病的了解。