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Tumor Cell-Microenvironment Interactions in the Molecular Pathogenesis of Multipl

Tumor Cell-Microenvironment Interactions in the Molecular Pathogenesis of Multipl
肿瘤细胞-微环境相互作用在多种肿瘤分子发病机制中的作用
批准号:
7725606
负责人:
John Damian Shaughnessy
金额:
$28.61万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-07-01 至 2014-06-30
关键词:
AllelesArchivesAttenuatedBenignBindingBiologyBone DiseasesBone MarrowBortezomibCDH1 geneCadherinsCarcinomaCell AdhesionCell LineCell ProliferationCellsClinicalCodeComplexConsensus SequenceDNA Modification ProcessDNA SequenceDataDerivation procedureDiseaseDisease ProgressionDown-RegulationDrug resistanceE-CadherinEnhancersEventExhibitsExtracellular MatrixExtramedullaryFoundationsGene ExpressionGene Expression ProfilingGene FrequencyGene MutationGenesGeneticGenetic PolymorphismGenetic TranscriptionGoalsGrowthHomologous GeneIn VitroInstructionInterleukin-9LengthLesionLinkLongitudinal StudiesLuciferasesLytic Metastatic LesionMagnetic Resonance ImagingMalignant NeoplasmsMeasuresMediatingMesenchymal Stem CellsMessenger RNAMolecularMonoclonal gammopathy of uncertain significanceMultiple MyelomaMutationN-CadherinNatural HistoryNeoplasm MetastasisNuclearNucleotidesOsteoblastsOsteolyticPathogenesisPathway interactionsPatientsPatternPlasma CellsPlasminProtein IsoformsProteinsPublishingQuality of lifeRecombinantsRegulationResearch PersonnelResistanceRoleSCID-hu MiceSamplingSignal TransductionSiteSolid NeoplasmStagingTCF Transcription FactorTherapeuticTissuesTumor Suppressor ProteinsUp-RegulationVariantWestern BlottingWorkWound Healingangiogenesisbasebonecell growthchemotherapychromatin immunoprecipitationcyr61 proteinepithelial to mesenchymal transitiongain of functionimprovedin vivoinnovationinsightlenalidomideloss of functionmalignant breast neoplasmmouse modelneoplastic cellnovelnovel therapeutic interventionosteoblast differentiationoverexpressionprogramspromoterranpirnasesyndecantherapeutic targettranscription factortumortumor growthtumor progression

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Bioinformatics Core
  • 批准号:
    10745014
  • 项目类别:
  • 资助金额:
    $13.74万
  • 财政年份:
    2023
  • 负责人:
    John Damian Shaughnessy
  • 依托单位:
Genomics and Proteomics
  • 批准号:
    7725624
  • 项目类别:
  • 资助金额:
    $33.65万
  • 财政年份:
    2009
  • 负责人:
    John Damian Shaughnessy
  • 依托单位:
MOLECULAR GENETICS OF CHROMOSOME 13 DELETIONS
  • 批准号:
    6594582
  • 项目类别:
  • 资助金额:
    $27.95万
  • 财政年份:
    2002
  • 负责人:
    John Damian Shaughnessy
  • 依托单位:
Molecular Diagnosis and Prognosis of Multiple Myeloma
  • 批准号:
    6766736
  • 项目类别:
  • 资助金额:
    $46.06万
  • 财政年份:
    2002
  • 负责人:
    John Damian Shaughnessy
  • 依托单位:
海外基金