3rd ASM Conference on Salmonella

描述（由申请人提供）：我们正在申请资金，为将于2009年10月5日至9日在法国普罗旺斯艾克斯举行的第三届ASM沙门氏菌会议提供支持。本次会议由美国微生物学会主办，该学会提供管理专业知识和资金支持。会议计划以2003年9月20日至24日在意大利撒丁岛和2006年9月9日至13日在加拿大不列颠哥伦比亚省维多利亚举行的前两次ASM沙门氏菌会议为基础。这个系列会议是唯一一个涵盖沙门氏菌研究所有方面的会议。之前的两次ASM沙门氏菌会议都参加得很好，我们预计来自世界各地的与会者将达到300-350人。拟议的计划具有广泛的科学重点，并将包括以下会议：进化，遗传学和生理学，动物感染和食品安全，免疫学和疫苗和发病机制。受邀演讲者的名单将包括该领域的许多杰出科学家，特别强调那些在以前的会议上没有做过口头报告的科学家、妇女和代表性不足的少数群体。我们相信，这次会议将为科学家们提供一个展示该领域最新进展的场所，并启动跨学科的互动和讨论。沙门氏菌在人类和其他动物中引起多种疾病，从肠胃炎到肠道热。在发达国家，包括伤寒、肠炎、海德堡和都柏林在内的非伤寒血清型（NTS）是常见的食源性病原体。其他不太常见的血清型，如果被引入食物链，就会引起疾病，最近在美国圣保罗爆发的疫情就很好地说明了这一点。在美国，与包括弯曲杆菌和志贺氏菌在内的其他常见食源性感染不同，NTS在过去一年中没有显示出任何减少的迹象，尽管采取了重大努力来限制养殖家禽和其他动物的细菌负担。NTS与艾滋病毒密切相关，因为在免疫功能低下的患者中，它可引起严重的全身性疾病，并且现在是许多撒哈拉以南非洲国家菌血症的最常见原因。伤寒和副伤寒是由血清型引起的，只感染人类和高等灵长类动物。这些疾病每年造成2 000多万人感染，仅伤寒就造成20多万人死亡。沙门氏菌的耐药菌株正在出现，其中一些是在食用动物中非治疗性使用抗生素的结果。会议将为沙门氏菌研究界提供一个论坛，展示和讨论最新的进展和想法。本次会议涵盖的广泛主题，从基础遗传学和生理学到发病机制和耐药性，将促进跨学科的互动，并最终加速旨在控制和治疗沙门氏菌感染的研究。

DESCRIPTION (provided by applicant): We are requesting funds to provide support for the 3rd ASM Salmonella conference to be held from 5-9 October 2009 in Aix-en-Provence, France. This conference is sponsored by the American Society for Microbiology, which provides both management expertise and financial support. The conference program is based upon the two previous ASM Conferences on Salmonella, which were held from 20-24 September 2003, in Sardinia, Italy and from 9-13 September 2006, in Victoria, BC, Canada. This conference series is the only one that covers all aspects of Salmonella research. Both of the preceding ASM Salmonella conferences were well attended and we expect 300-350 attendees from around the world. The proposed program has a broad scientific focus and will include sessions on; Evolution, Genetics and Physiology, Animal Infections and Food Safety, Immunology and Vaccines and Pathogenesis. The list of invited speakers will include many of the preeminent scientists in the field, with special emphasis on those who have not given oral presentations at the previous meetings, women and underrepresented minority groups. We are confident that the meeting will provide a venue for scientists to present the latest advances in the field and to initiate interdisciplinary interactions and discussion. Public Health Relevance Statement Salmonellae cause a variety of diseases, ranging from gastroenteritis to enteric fever, in humans and other animals. In the developed world non-typhoidal serovars (NTS) including Typhimurium, Enteritidis, Heidelberg and Dublin are common food borne pathogens. Other less common serovars, can cause disease if introduced into the food chain, as has been well illustrated by the recent SaintPaul outbreak in the US. In the US unlike other common food borne infections, including Campylobacter and Shigella, NTS has not shown any signs of decreasing in the last despite major efforts to limit the bacterial burden in farmed poultry and other animals. NTS has a strong association with HIV, since in immunocompromised patients it can cause a severe systemic disease, and is now the most common cause of bacteremia in many sub-Saharan African countries. The enteric fevers, Typhoid and Paratyphoid, are caused by serovars that only infect humans and higher primates. These diseases cause over 20 million infections per year and typhoid alone is responsible for over 200,000 deaths. Drug resistant strains of Salmonella are appearing - some as the result of nontherapeutic use of antibiotics in food producing animals. The conference will provide a forum for the Salmonella research community to present and discuss the most recent advances and ideas. The broad spectrum of subjects covered at this conference, from basic genetics and physiology to pathogenesis and drug resistance, will facilitate interdisciplinary interactions and ultimately accelerate research aimed at controlling and treating Salmonella infections.