Nucleosides, Nucleotides and Oligonucleotides GRC 2009

描述(由申请人提供)：本提案请求部分支持将于2009年7月5-10日在里约热内卢的萨尔维里贾纳大学举行的关于核苷、核苷酸和寡核苷酸的会议，作为戈登研究会议系列的一部分。会议的广泛和长期目标是增加我们对核苷、核苷酸和寡核苷酸化学的理解。这些药物作为诊断工具和治疗危及生命的疾病的药物的生物学意义将补充化学。本次会议的具体目标是召集9位讨论领袖主持9场会议。大会主席和副主席将对整个会议进行监督。将有27位演讲者代表核苷、核苷酸和寡核苷酸的化学和生物学关键领域。该计划将有一次主旨演讲和八次会议，广泛讨论DNA复制、DNA修复、RNA转录、基因表达的控制、作为治疗剂的核苷类似物、它们的运输和代谢以及核酸和核苷类似物的化学等当前问题。此外，两个晚上的海报会议将允许所有参与者为这些主题做出贡献。这一应用的意义在于，戈登研究会议是专注于核苷、核苷酸和寡核苷酸的化学家和生物学家聚集在一起的唯一平台。由于核苷类似物通过不同的作用机制，对实体肿瘤和血液系统恶性肿瘤以及包括艾滋病在内的几种病毒疾病的治疗非常有效，因此这次会议具有非常重要的意义，因为它与健康有关。化学家和科学家之间的讨论将产生新的知识和发展新疗法的途径。同样，寡核苷酸已成为疾病预后和诊断的主要工具。实时逆转录聚合酶链式反应、聚合酶链式反应、反义寡核苷酸、核酶、RNAi、微RNA和微阵列在疾病诊断、预后和治疗的几个步骤中被使用。我们专注于这些领域的会议将产生新的知识和合作。 公共卫生相关性：这项申请的意义在于，戈登研究会议是唯一一个将专注于核苷、核苷酸和寡核苷酸的化学家和生物学家聚集在一起的平台。由于核苷类似物对实体肿瘤和血液系统恶性肿瘤以及包括艾滋病在内的几种病毒疾病的治疗都非常有效，因此这次会议具有非常重要的健康意义。化学家和科学家之间的讨论将产生新的知识和发展新疗法的途径。同样，寡核苷酸已成为疾病预后和诊断的主要工具。实时逆转录聚合酶链式反应、聚合酶链式反应、反义寡核苷酸、核酶、RNAi、微RNA和微阵列在疾病诊断、预后和治疗的几个步骤中被使用。我们专注于这些领域的会议将产生新的知识和合作。

DESCRIPTION (provided by applicant): This proposal requests partial support for a meeting on Nucleosides, Nucleotides, and Oligonucleotides as part of the Gordon Research Conference series to be held in Salve Regina University, Newport, RI from July 5 - 10, 2009. The broad and long term goal of the conference is to increase our understanding of the chemistry of nucleosides, nucleotides, and oligonucleotides. The biological significance of these agents as tools for diagnosis and as drugs for treatment of life-threatening diseases will complement the chemistry. The specific aims of this meeting will be to convene nine discussion leaders to moderate nine sessions. Chair and vice chairs of the conference will supervise the whole conference. There will be 27 speakers who will represent critical areas of the chemistry and biology of nucleosides, nucleotides, and oligonucleotides. The program will have a keynote address and eight sessions that broadly address current issues in DNA replication, DNA repair, RNA transcription, control of gene expression, nucleoside analogues as therapeutic agents, their transport and metabolism, and chemistry of nucleic acids and nucleoside analogues. In addition, two evening poster sessions will permit all participants to contribute to these topics. The significance of this application is that the Gordon Research Conference is the only platform where chemists and biologists who focus on nucleosides, nucleotides, and oligonucleotides come together. Because nucleoside analogues, acting by diverse mechanisms, are highly effective for treatment of solid tumor and hematological malignancies and several viral diseases including AIDS, this conference is highly significant regarding its health relatedness. The discussions among chemists and scientists will generate new knowledge and avenues for development of novel therapeutics. Similarly, oligonucleotides have become major tools for prognosis and diagnosis of diseases. Real time RT-PCR, PCR, antisense oligonucleotides, ribozymes, RNAI, microRNAs and microarrays are used at several steps in disease diagnosis, prognosis, and treatment. Our conference focusing on these areas will generate new knowledge and collaborations. Public Health Relevance: The significance of this application is that the Gordon Research Conference is the only platform where chemists and biologists who focus on 'nucleosides, nucleotides, and oligonucleotides' come together. Because nucleoside analogues are highly effective for treatment of solid tumor and hematological malignancies and several viral diseases including AIDS, this conference is highly significant regarding its health relatedness. The discussions among chemists and scientists will generate new knowledge and avenues for development of novel therapeutics. Similarly, oligonucleotides have become major tools for prognosis and diagnosis of diseases. Real time RT- PCR, PCR, antisense oligonucleotides, ribozymes, RNAI, microRNAs and microarrays are used at several steps in disease diagnosis, prognosis, and treatment. Our conference focusing on these areas will generate new knowledge and collaborations.