2009 Proteins Gordon Conference

2009 年蛋白质戈登会议

• 批准号: 7673044
• 负责人: TERRENCE GILBERT OAS
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7673044
• 关键词: Biological; Biological Process; Biology; Cells; Communities; Conscious; Disease; Foundations; Functional disorder; Funding; Future; Gene Expression; Health; Heterogeneity; Human; Hydrogen Bonding; Hydrophobicity; Lead; Ligand Binding; Measures; Metabolism; Motion; Mutation; Participant; Pharmaceutical Preparations; Property; Proteins; Research; Role; Schedule; Science; Scientist; Senior Scientist; Signal Pathway; Structure; Suggestion; Update; Veins; Water; Work; abstracting; amyloid formation; design; insight; meetings; programs; protein function; public health relevance; response; solute; symposium; theories; therapeutic target; trend

DESCRIPTION (provided by applicant): Project abstract Funds are requested to support the 2009 Proteins Gordon Research Conference. This is a long-standing and usually oversubscribed meeting that serves the scientific community and is focused on the fundamental properties of protein molecules, including their structure, folding, dynamics, stability, and interactions. As vice chairs of the 2007 meeting, Fetrow and Oas participated in a conscious decision on the part of chairs Hill and Pielak to incorporate a more cellular focus in the session and talk topics. This updating of Proteins was generally well received by the participants of the 2007 meeting and we have developed a program that continues in this vein. However, we have also recognized that the participation of the scientists who laid the foundation for modern protein science was lower in 2007 than in previous years. To increase their participation, we have developed a program designed to provide younger protein scientists with the insights and perspectives accomplished senior leaders of the field can provide. These senior scientists will chair sessions whose topics their work has significantly impacted. They will present talks at the beginning or end of their session, which will provide historical context to exciting new sub-fields of protein science and lead the 30-minute discussions at the end of each session. Speakers in each session include younger scientists, whose work focuses on proteins in their biological context. In this way, we will bring together the best of classical protein science with the best of the newer research in the field. In choosing topics and speakers for the 2009 meeting, we sought input from the protein science community and have incorporated suggestions offered in response to the 2007 program. The current co-vice chairs, Clark and Bowie, are also heavily involved in planning the 2009 meeting. In response to a criticism of the 2007 meeting, we are planning several measures to increase the interaction between all meeting participants, particularly the senior and junior scientists. In addition to a final keynote session, the 2009 schedule includes the following regular sessions: 1. Post-reductionist protein science; 2. Role of co-solutes and water in protein stability; 3. Protein-RNA biology; 4. The hydrogen bond and hydrophobicity, revisited; 5. Theory of amyloid formation; 6. Functional consequences of protein heterogeneity; 7. Protein function and ligand binding in the cell. Public Health Relevance: Project narrative, including health-related significance Proteins are central actors in most biological processes, including those relevant to human health. Proteins are involved in such important biological processes as signaling pathways, metabolism, and gene expression. They are the usual targets of therapeutic drugs and protein mutation, mis-folding or dysfunction is directly implicated in many diseases. The 2009 Proteins GRC will explore recent advances and future trends in understanding the structure, stability, motions, and interactions of protein molecules and how these fundamental properties impact function in the biological context.

描述（由申请人提供）： 项目摘要 请求资金支持 2009 年蛋白质戈登研究会议。这是一个长期存在且通常超额认购的会议，为科学界服务，重点关注蛋白质分子的基本特性，包括其结构、折叠、动力学、稳定性和相互作用。作为 2007 年会议的副主席，Fetrow 和 Oas 参与了主席 Hill 和 Pielak 的一项有意识的决定，即在会议和谈话主题中纳入更多的细胞焦点。蛋白质的更新受到了 2007 年会议参与者的普遍好评，我们已经开发了一个延续这一思路的计划。然而，我们也认识到，2007年奠定现代蛋白质科学基础的科学家的参与程度低于往年。为了增加他们的参与，我们开发了一个计划，旨在为年轻的蛋白质科学家提供该领域高级领导者可以提供的见解和观点。这些资深科学家将主持其工作对其主题产生重大影响的会议。他们将在会议开始或结束时发表演讲，为令人兴奋的蛋白质科学新子领域提供历史背景，并在每场会议结束时主持 30 分钟的讨论。每场会议的演讲者都包括年轻的科学家，他们的工作重点是生物学背景下的蛋白质。通过这种方式，我们将把经典蛋白质科学的精华与该领域最新研究的精华结合在一起。在选择 2009 年会议的主题和发言人时，我们征求了蛋白质科学界的意见，并采纳了针对 2007 年会议提出的建议。现任联合副主席克拉克和鲍伊也积极参与 2009 年会议的筹划。为了回应对 2007 年会议的批评，我们正在计划采取几项措施来增加所有会议参与者，特别是高级和初级科学家之间的互动。除了最后的主题演讲之外，2009 年的日程还包括以下常规会议： 1. 后还原论蛋白质科学； 2. 共溶质和水对蛋白质稳定性的作用； 3. 蛋白质-RNA生物学； 4. 重新审视氢键和疏水性； 5.淀粉样蛋白形成理论； 6. 蛋白质异质性的功能后果； 7. 细胞内的蛋白质功能和配体结合。 公共卫生相关性：项目叙述，包括与健康相关的重要性蛋白质是大多数生物过程的核心参与者，包括与人类健康相关的生物过程。蛋白质参与信号传导途径、代谢和基因表达等重要的生物过程。它们是治疗药物的常见靶点，蛋白质突变、错误折叠或功能障碍与许多疾病直接相关。 2009 年蛋白质 GRC 将探讨了解蛋白质分子的结构、稳定性、运动和相互作用以及这些基本特性如何影响生物环境中的功能的最新进展和未来趋势。