2009 Mammalian Gametogenesis

2009 哺乳动物配子发生

• 批准号: 7672650
• 负责人: MICHAEL K SKINNER
• 金额: $ 0.8万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7672650
• 关键词: Address; Agriculture; Animals; Area; Basic Science; Biological; Biological Preservation; Cell Cycle Regulation; Cells; Collaborations; Congenital Abnormality; Contraceptive Agents; Contraceptive methods; Developing Countries; Development; Embryo; Embryonic Development; Engineering; Fostering; Funding; Gametogenesis; Germ Cells; Grant; Human; Infertility; Institutes; International; Joints; Letters; Methodology; Modeling; Molecular; National Center for Research Resources; National Human Genome Research Institute; National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; New Hampshire; Nuclear; Participant; Patients; Pluripotent Stem Cells; Population Growth; Prenatal Diagnosis; Prevention; Production; Recording of previous events; Reproductive Biology; Request for Applications; Research Personnel; Resort; Scientist; Techniques; Therapeutic; Time; United States National Institutes of Health; Women' s Health; base; egg; meetings; novel strategies; pressure; programs; public health relevance; sperm cell; symposium

DESCRIPTION (provided by applicant): This application requests partial funding for the 17th Gordon Conference on Mammalian Gametogenesis and Embryogenesis to be held August 2-7, 2009 at Waterville Valley Resort in Waterville Valley, New Hampshire. Based on the scientific content of this meeting, as well as previous granting history, and recent discussions with NIH program officers, we request that the National Institute of Child Health and Human Development be designated the primary sponsor of this meeting (letter of acceptance from NICHD is appended). However, as the content of this meeting is also relevant to areas targeted by other institutes, we request joint sponsorship by the National Institute of Environmental Health Sciences, the NIH Office of Women's Health, the National Human Genome Research Institute, the National Center for Research Resources, and the National Institute of General Medical Sciences. The diversity of the topics to be addressed at this conference will be reflected in the diversity of the participants. This conference provides a unique and valuable opportunity for discussion and the exchange of ideas between clinicians devoted to delivering the most modern therapeutic approaches to their patients, and basic scientists who are examining the biological mechanisms that underlie normal and abnormal function of gametogenesis and embryogenesis. Understanding the molecular mechanisms underlying the production of viable eggs and sperm and the initiation of embryonic development is essential for the continued survival of animal species in the 21st century and beyond. Advances in reproductive biology have immediate application, not only for the treatment of human infertility and subfertility, but also for improvements in developing contraceptive methods, advances in agricultural engineering and novel approaches to wildlife preservation. Moreover, as stem cells, pluripotent cells, gametes and early embryos provide important models for basic research aimed at understanding nuclear programming and cell cycle regulation, as well as transcriptional, translational, and post-translational control mechanisms. These areas have potential significance for a wide variety of biomedical applications. The objective of the Gordon Conference on Mammalian Gametogenesis and Embryogenesis is to provide a forum for the exchange of the latest advances in the field, as well as to promote discussion and debate by providing a relaxed setting that fosters interaction. A particularly important aspect of the Gordon Conference setting is the blending of young and established investigators, as well as national and international scientists to promote exchanges that will generate new ideas and facilitate new collaborations. PUBLIC HEALTH RELEVANCE: Societal pressure for advancements in the field of reproductive biology is stronger in the 21st century than at any time in recorded history. New techniques for the treatment of human infertility, for improvements in prenatal diagnosis and in the prevention of birth defects, and for the control of population growth via the development of new contraceptive methodologies are essential to meet the needs of both developed and third world countries.

描述（由申请人提供）： 本申请要求为将于2009年8月2日至7日在新罕布什尔州沃特维尔谷的沃特维尔谷度假村举行的第17届戈登哺乳动物配子发生和胚胎发生会议提供部分资金。根据本次会议的科学内容，以及以前的资助历史，以及最近与NIH项目官员的讨论，我们要求指定国家儿童健康和人类发展研究所为本次会议的主要赞助商（NICHD的接受函附后）。但是，由于本次会议的内容也与其他机构的目标领域有关，我们请求国立环境健康科学研究所、NIH妇女健康办公室、国立人类基因组研究所、国立研究资源中心和国立普通医学科学研究所共同赞助。本次会议将讨论的主题的多样性将反映在与会者的多样性上。本次会议提供了一个独特而宝贵的机会，供致力于为患者提供最现代治疗方法的临床医生和正在研究配子发生和胚胎发生正常和异常功能的生物学机制的基础科学家之间进行讨论和交流。了解产生活卵和精子的分子机制以及胚胎发育的启动对于动物物种在21世纪及以后的持续生存至关重要。生殖生物学的进展不仅可用于治疗人类不育和生育力低下，而且可用于改进避孕方法的开发、农业工程的进展和野生动物保护的新方法。此外，作为干细胞，多能细胞、配子和早期胚胎为旨在理解核编程和细胞周期调控以及转录、翻译和翻译后控制机制的基础研究提供了重要模型。这些领域对各种生物医学应用具有潜在意义。戈登哺乳动物配子发生和胚胎发生会议的目标是为交流该领域的最新进展提供一个论坛，并通过提供一个促进互动的轻松环境来促进讨论和辩论。戈登会议环境的一个特别重要的方面是年轻和成熟的研究人员以及国家和国际科学家的融合，以促进交流，产生新的想法，促进新的合作。 公共卫生相关性： 在生殖生物学领域取得进步的社会压力在世纪比有史以来的任何时候都要大。治疗人类不育症、改进产前诊断和预防出生缺陷以及通过发展新的避孕方法控制人口增长的新技术对满足发达国家和第三世界国家的需要至关重要。