Conference on Regulatory Myeloid Cells in Health and Diseases

描述（由申请人提供）：本次国际生物医学会议将于2009年3月12日至15日在佛罗里达克利尔沃特的喜来登沙键酒店举行。本次会议的目的是促进在新的快速发展的研究领域的最新发现和想法的交流：调节性骨髓抑制细胞。近年来，关于这些细胞在癌症、脓毒症、感染、创伤、自身免疫和其他病理中的重要作用的信息非常丰富。越来越多的证据表明，这些调节细胞的扩张可能代表了对所有形式炎症的共同反应。许多研究表明，这些细胞可能是调节性T细胞的髓样类似物，因为它们对各种刺激的高可塑性和抑制持续免疫反应的高潜力。目前有几项临床试验靶向这些细胞，目的是改善癌症的免疫反应。然而，该领域以及术语“调节性髓样细胞”是高度有争议的，许多问题仍未解决。现在似乎是一个绝佳的时机，将来自不同领域的科学家聚集在一起，在癌症和其他疾病免疫学的广泛背景下讨论这些细胞的扩增，积累，分化，调节和功能的各个方面。整个领域迫切需要讨论已经描述过的机制和新出现的机制，看看如何将它们放在一起，形成一个或多或少有凝聚力的结构。特别强调将放在新的方法来治疗癌症和其他疾病中的调节性骨髓细胞的积累。这次会议的总体目标是： * 评估我们对髓系抑制细胞在不同病理条件下的作用的理解的最新进展; * 检查不同的分子途径如何有助于骨髓抑制细胞的功能，并影响癌症，创伤，自身免疫和感染性疾病的免疫反应; * 评估癌症和其他疾病中免疫抑制的不同机制; * 讨论这些机制对不同病理条件治疗的影响; * 回顾并讨论我们对髓系抑制细胞的了解如何转化为新的治疗方法。 公共卫生相关性：近年来，关于免疫抑制性骨髓细胞在癌症、脓毒症、感染、创伤、自身免疫和其他病理中的重要作用的信息非常丰富。越来越多的证据表明，这些调节细胞的扩增可能代表了对所有形式炎症的共同反应。许多研究表明，这些细胞可以是调节性T细胞的髓样类似物，因为它们响应于各种刺激的高可塑性和抑制正在进行的免疫应答的高潜力。一些临床试验靶向这些细胞，目的是改善癌症的免疫反应。然而，该领域以及术语“调节性髓样细胞”是高度有争议的，许多问题仍未解决。现在似乎是一个很好的时机，将来自不同领域的科学家聚集在一起，在癌症和其他疾病免疫学的广泛背景下讨论这些细胞的扩增，积累，分化，调节和功能的各个方面。我们计划将来自不同研究领域的科学家聚集在一起，研究骨髓源性抑制细胞（MDSC），调节（抑制）树突状细胞以及抑制性巨噬细胞。我们希望这次会议能产生富有成效的讨论，促进新的合作，有助于这一领域的发展。除了专门的会议，我们计划有几个全体讲座的科学家谁不一定参与骨髓抑制细胞的研究，但他们的工作可能会直接影响这一领域。会议将于2009年3月12日至3月15日在喜来登沙键度假村，1160海湾大道，清水海滩，佛罗里达州33767位于皮内拉斯阳光海岸，仅21英里以西的坦帕国际机场。

DESCRIPTION (provided by applicant): This international biomedical conference will be held March 12-15, 2009 at Sheraton Sand Key Hotel in Clearwater, Florida. The purpose of this meeting is to foster exchange of the most recent findings and ideas in novel rapidly developed field of research: regulatory myeloid suppressor cells. Recent years have brought a wealth of information about the important role of these cells in cancer, sepsis, infections, trauma, autoimmunity, and other pathologies. There is growing evidence pointing out on that the expansion of these regulatory cells may represent a common response to all forms of inflammation. A number of studies have suggested that these cells can be a myeloid analog of regulatory T cells due to their high plasticity in response to various stimuli and high potential to suppress ongoing immune responses. Several clinical trails currently target these cells with the goal to improve the immune response in cancer. However, the field as well as the term "regulatory myeloid cells" is highly controversial and many issues remain unresolved. It appears that it is now an excel- lent time to bring together scientists from different fields to discuss various aspects of the expansion, accumulation, differentiation, regulation, and function of these cells in a broad context of immunology of cancer and other diseases. There is a pressing need for the entire field to discuss already described and new emerging mechanisms to see how they can be put together in more or less cohesive structure. Special emphasis will be placed on new approaches to therapeutic correction of accumulation of regulatory myeloid cells in cancer and other diseases. The overall objectives of this conference are: * Assess recent progress in our understanding of the role of myeloid suppressor cells in different pathological conditions; * Examine how different molecular pathways contribute to the function of myeloid suppressive cells and affect immune response in cancer, trauma, autoimmune, and infectious diseases; * Evaluate different mechanisms of immune suppression in cancer and other diseases; * Discuss impact of these mechanisms of therapy of different pathological conditions; * Review and discuss how our knowledge of myeloid suppressor cells can be translated into new therapeutics. Public Health Relevance: Recent years have brought a wealth of information about the important role of immune suppressive myeloid cells in cancer, sepsis, infections, trauma, autoimmunity, and other pathologies. There is growing evidence to suggest that the expansion of these regulatory cells may represent a common response to all forms of inflammation. A number of studies have suggested that these cells can be a myeloid analog of regulatory T cells due to their high plasticity in response to various stimuli and high potential to sup- press ongoing immune responses. Several clinical trails target these cells with the goal to improve the immune response in cancer. However, the field as well as the term "regulatory myeloid cells" is highly controversial and many issues remain unresolved. It appears that it is an excellent time now to bring together scientists from different fields to discuss various aspects of the expansion, accumulation, differentiation, regulation, and function of these cells in a broad context of immunology of cancer and other diseases. We plan to bring together scientists from diverse areas of research working on myeloid-derived suppressor cells (MDSC), regulatory (suppressive) dendritic cells, as well as suppressive macrophages. We hope that this meeting generates productive discussion and fosters new collaborations, helpful for the development of this field. In addition to specialized sessions, we plan to have several plenary lectures presented by scientists who are not necessarily involved in study of myeloid suppressive cells but whose work may directly impact this field. The conference will be held from March 12 through March 15 2009 at Sheraton Sand Key Resort, 1160 Gulf Bulevard, Clearwater Beach, FL 33767 located on the Pinellas Suncoast, just 21 miles west of the Tampa International Airport.