Conference on Regulatory Myeloid Cells in Health and Diseases

健康与疾病中的调节性骨髓细胞会议

基本信息

批准号：
7668871
负责人：
Dmitry I Gabrilovich
金额：
$ 0.6万
依托单位：
H. LEE MOFFITT CANCER CTR & RES INST
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-04-23 至 2010-03-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): This international biomedical conference will be held March 12-15, 2009 at Sheraton Sand Key Hotel in Clearwater, Florida. The purpose of this meeting is to foster exchange of the most recent findings and ideas in novel rapidly developed field of research: regulatory myeloid suppressor cells. Recent years have brought a wealth of information about the important role of these cells in cancer, sepsis, infections, trauma, autoimmunity, and other pathologies. There is growing evidence pointing out on that the expansion of these regulatory cells may represent a common response to all forms of inflammation. A number of studies have suggested that these cells can be a myeloid analog of regulatory T cells due to their high plasticity in response to various stimuli and high potential to suppress ongoing immune responses. Several clinical trails currently target these cells with the goal to improve the immune response in cancer. However, the field as well as the term "regulatory myeloid cells" is highly controversial and many issues remain unresolved. It appears that it is now an excel- lent time to bring together scientists from different fields to discuss various aspects of the expansion, accumulation, differentiation, regulation, and function of these cells in a broad context of immunology of cancer and other diseases. There is a pressing need for the entire field to discuss already described and new emerging mechanisms to see how they can be put together in more or less cohesive structure. Special emphasis will be placed on new approaches to therapeutic correction of accumulation of regulatory myeloid cells in cancer and other diseases. The overall objectives of this conference are: * Assess recent progress in our understanding of the role of myeloid suppressor cells in different pathological conditions; * Examine how different molecular pathways contribute to the function of myeloid suppressive cells and affect immune response in cancer, trauma, autoimmune, and infectious diseases; * Evaluate different mechanisms of immune suppression in cancer and other diseases; * Discuss impact of these mechanisms of therapy of different pathological conditions; * Review and discuss how our knowledge of myeloid suppressor cells can be translated into new therapeutics. Public Health Relevance: Recent years have brought a wealth of information about the important role of immune suppressive myeloid cells in cancer, sepsis, infections, trauma, autoimmunity, and other pathologies. There is growing evidence to suggest that the expansion of these regulatory cells may represent a common response to all forms of inflammation. A number of studies have suggested that these cells can be a myeloid analog of regulatory T cells due to their high plasticity in response to various stimuli and high potential to sup- press ongoing immune responses. Several clinical trails target these cells with the goal to improve the immune response in cancer. However, the field as well as the term "regulatory myeloid cells" is highly controversial and many issues remain unresolved. It appears that it is an excellent time now to bring together scientists from different fields to discuss various aspects of the expansion, accumulation, differentiation, regulation, and function of these cells in a broad context of immunology of cancer and other diseases. We plan to bring together scientists from diverse areas of research working on myeloid-derived suppressor cells (MDSC), regulatory (suppressive) dendritic cells, as well as suppressive macrophages. We hope that this meeting generates productive discussion and fosters new collaborations, helpful for the development of this field. In addition to specialized sessions, we plan to have several plenary lectures presented by scientists who are not necessarily involved in study of myeloid suppressive cells but whose work may directly impact this field. The conference will be held from March 12 through March 15 2009 at Sheraton Sand Key Resort, 1160 Gulf Bulevard, Clearwater Beach, FL 33767 located on the Pinellas Suncoast, just 21 miles west of the Tampa International Airport.

描述（由申请人提供）：这次国际生物医学会议将于2009年3月12日至15日在佛罗里达州克莱尔沃特的Sheraton Sand Key Hotel举行。这次会议的目的是促进新型研究领域的最新发现和思想交换：调节性髓样抑制细胞。近年来，有关这些细胞在癌症，败血症，感染，创伤，自身免疫性和其他病理学中的重要作用的大量信息。越来越多的证据指出，这些调节细胞的扩展可能代表对所有形式的炎症的共同反应。许多研究表明，这些细胞可能是调节性T细胞的髓样类似物，因为它们的高可塑性响应各种刺激，并且具有抑制持续免疫反应的高潜力。目前，几个临床径瞄准了这些细胞，目的是改善癌症的免疫反应。但是，该领域以及“调节性髓样细胞”一词是高度争议的，许多问题仍未解决。现在看来，在癌症和其他疾病免疫学的广泛背景下，这些细胞的扩张，积累，分化，调节和功能的各个方面都将来自不同领域的科学家聚集在一起。整个领域都需要讨论已经描述的整个领域以及新的新兴机制，以查看如何将它们放在或多或少的凝聚力结构中。将特别重点放在癌症和其他疾病中调节性髓样细胞积累的新方法上。这次会议的总体目标是： *评估我们对髓样抑制细胞在不同病理条件下的作用的最新进展； *检查不同的分子途径如何促进髓样抑制细胞的功能，并影响癌症，创伤，自身免疫性和感染性疾病的免疫反应； *评估癌症和其他疾病中免疫抑制的不同机制； *讨论不同病理状况治疗机制的影响； *审查并讨论我们如何将我们对髓样抑制细胞的了解转化为新的治疗剂。公共卫生相关性：近年来，已经为免疫抑制性髓样细胞在癌症，败血症，感染，创伤，自身免疫性和其他病理学中的重要作用带来了丰富的信息。越来越多的证据表明，这些调节细胞的扩展可能代表对所有形式的炎症的共同反应。许多研究表明，这些细胞可能是调节性T细胞的髓样类似物，因为它们的高可塑性响应各种刺激，并且很高的潜力以压缩持续的免疫反应。几个临床步道以这些细胞为目标，目的是改善癌症的免疫反应。但是，该领域以及“调节性髓样细胞”一词是高度争议的，许多问题仍未解决。现在看来，现在是从不同领域汇集科学家来讨论这些细胞在癌症和其他疾病免疫学的广泛背景下的扩张，积累，分化，调节和功能的各个方面的绝佳时机。我们计划将研究髓样衍生的抑制细胞（MDSC），调节性（抑制）树突状细胞以及抑制性巨噬细胞的研究领域的科学家聚集在一起。我们希望这次会议能够产生富有成效的讨论，并促进新的合作，对这一领域的发展有所帮助。除了专业会议外，我们计划进行几次大规模讲座，由科学家介绍，他们不一定参与研究髓样抑制细胞的研究，但其工作可能直接影响该领域。该会议将于2009年3月12日至15日在佛罗里达州Clearwater Beach，Clearwater Beach 1160 Bulevard的Sheraton Sand Key Resort举行，位于坦帕国际机场以西21英里处的Pinellas Suncoast上。