Systems Level Understanding of DNA Damage Responses

描述（由申请人提供） 本申请的目的是申请资金，以支持将于2009年3月30日至4月1日在荷兰埃格蒙德的Zuiderduin酒店举行的第三届欧洲联盟（欧盟）/美国（美国）研讨会“DNA损伤反应的系统水平理解”。2009年的第三次会议将完善DNA损伤反应网络在人类疾病中的作用，并将进一步描述通过DNA损伤反应网络变化所表现出的对环境暴露的反应。产生DNA损伤的环境暴露可能包括化学致癌物，如香烟烟雾中的烷基化和氧化剂以及重金属，杀虫剂和工业化学品。此外，在我们的自然环境中发现的物理破坏剂，包括与氡气有关的电离辐射和与晒伤有关的紫外线辐射，也是可能导致DNA损伤和促进癌症的主要暴露源。每一种化学和物理接触类型都有损害DNA的倾向，这些制剂将在会议上结合复员方案进行讨论。第三届欧盟/美国联合研讨会的目标有两个：（1）评估DDR的当前科学，特别关注全球和网络层面对导致DNA损伤的环境暴露的反应的影响，以及综合DDR信号通路在人类疾病病因学中的作用;（2）为欧盟和美国在DDR研究的相关领域建立互惠科学交流计划奠定基础。

DESCRIPTION (provided by applicant) The purpose of this application is to request funds to support the 3rd European Union (EU)/United States (US) Workshop on "Systems Level Understanding of DNA Damage Responses" to be held at Hotel Zuiderduin inEgmond aan Zee, Netherlands from March 30 to April 1, 2009. This third meeting in 2009 will refine the role of DNA damage response (DDR) networks in human disease and will further characterize responses to environmental exposures that are expressed through changes in DDR. Environmental exposures that produce DNA damage can include chemical carcinogens, represented as alkylating and oxidizing agents and heavy metals found in cigarette smoke, pesticides and industrial chemicals. In addition, physical damaging agents found in our natural environment, which include ionizing radiation associated with radon gas and UV radiation associated with sunburns are also major sources of exposure that can cause DNA damage and promote cancer. Each of the chemical and physical exposure types has the propensity to damage DNA and these agents will be discussed at the meeting in the context of the DDR. The goals of this 3rd joint EU/US workshop are twofold: (1) to assess the current science of the DDR, with specific attention on the influence of global and network level responses to environmental exposures that cause DNA damage, and the role of integrated DDR signaling pathways in the etiology of human diseases and; (2) to establish the basis for a reciprocal scientific exchange program between the EU and the US in the relevant areas of DDR research.