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Non-invasive Hemodynamic Monitoring of Physiological Parameter

无创血流动力学生理参数监测

基本信息

批准号：
7894745
负责人：
Aaron M Dentinger
金额：
$ 81.55万
依托单位：
GENERAL ELECTRIC GLOBAL RESEARCH CTR
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-15 至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7894745
关键词：
3-Dimensional Acute Address Algorithms Animal Model Animals Aorta Architecture Area Arteries Atherosclerosis Attention Back Biophysics Blood Pressure Blood Vessels Blood flow Caliber Canis familiaris Cardiac Cardiovascular Diseases Cardiovascular system Caring Carotid Arteries Catheters Chronic Clinical Complex Conscious Coronary Development Devices Diagnostic Disease Early Diagnosis Electronics Event Feasibility Studies Future Goals Health Hypertension Image In Vitro Incidence Inflammation Intervention Laboratories Measurement Measures Medical center Methods Miniaturization Modeling Monitor Myocardial Infarction Nature Pathology Pharmacologic Substance Physicians Physiologic Monitoring Physiologic pulse Physiological Physiology Play Primary Care Physician Primary Health Care Process Research Role Screening procedure Staging Stroke Symptoms System Techniques Time Ultrasonography Underserved Population Universities Validation Variant Vascular Diseases arterial stiffness base clinical practice computerized data processing cost cost effective data acquisition effective therapy experience hemodynamics improved in vivo in vivo Model laptop macrophage miniaturize next generation pressure sensor sound trend vasa vasorum vasoactive agent

项目摘要

Driven by advances in electronic miniaturization, probe construction techniques and computing power, medical ultrasound is experiencing a trend toward smaller, lower cost systems with real-time volumetric imaging capabilities. These new attributes provide the opportunity to improve and expand the clinical utility of ultrasound to new applications. The combination of miniaturization and new attributes permits the expansion to previously underserved populations. Cardiovascular parameters for screening and monitoring, such as in a bedside or ambulatory setting, is one of these untapped areas that can benefit from quantitative, non-invasive measurements. Continuous and accurate measures of arterial parameters will provide additional information for earlier detection and more effective treatment of diseases, such as atherosclerosis and hypertension, while the clinical utility of any new measure will ultimately be determine by the reliability. Preliminary studies on in vitro and in vivo models have shown the potential of ultrasound hemodynamic measures in a laboratory setting. The proposal aims to develop and validate quantitative hemodynamic measures for new cardiovascular applications on next generation volumetric ultrasound systems. The technical development specifically focuses on reliable measurement algorithms for (1) quantitative arterial area and volumetric flow rate, (2) arterial compliance, and (3) continuous blood pressure. The approach utilizes volumetric ultrasound to provide structural information allowing typical qualitative ultrasound measures to be converted into quantitative measures. By combining volumetric ultrasound with automatic methods to locate the vessel and continuously process the data, the reliability and ease of use can be improved to the point where a sonographer is not required. A simplified 3-D architecture developed from existing hardware will be modified for these feasibility studies, and the ultrasound-based quantitative hemodynamic measures will be validated and the measurement variation quantified using invasive flow and pressure sensors under a variety of physiological conditions during acute and chronic studies in anesthetized and conscious canine models.

在电子小型化、探头构造技术和计算能力进步的推动下，医学超声正经历着向具有实时体积成像功能的更小、更低成本的系统发展的趋势。这些新属性提供了改进超声临床用途并将其扩展到新应用的机会。小型化和新属性的结合允许扩展到以前服务不足的人群。用于筛查和监测的心血管参数（例如在床边或门诊环境中）是可以从定量、非侵入性测量中受益的未开发领域之一。连续、准确的动脉参数测量将为动脉粥样硬化和高血压等疾病的早期检测和更有效的治疗提供额外的信息，而任何新测量的临床效用最终将由可靠性决定。体外和体内模型的初步研究显示了实验室环境中超声血流动力学测量的潜力。该提案旨在开发和验证下一代体积超声系统上新心血管应用的定量血流动力学测量。技术开发特别侧重于可靠的测量算法，用于 (1) 定量动脉面积和体积流量、(2) 动脉顺应性和 (3) 连续血压。该方法利用体积超声提供结构信息，允许将典型的定性超声测量转换为定量测量。通过将体积超声与自动方法相结合来定位血管并连续处理数据，可以将可靠性和易用性提高到不需要超声检查人员的程度。根据现有硬件开发的简化 3D 架构将针对这些可行性研究进行修改，并且将验证基于超声的定量血流动力学测量，并在麻醉和清醒犬模型的急性和慢性研究期间使用侵入式流量和压力传感器在各种生理条件下量化测量变化。