Brain-activity during sedation predicting post-sedation explicit-memory

镇静期间的大脑活动预测镇静后的外显记忆

• 批准号: 7745368
• 负责人: Adrian W. Gelb
• 金额: $ 43.73万
• 依托单位: ABRATECH CORPORATION
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7745368
• 关键词: Address; Affect; Anesthesia procedures; Anesthetics; Animals; Auditory; Brain; Breathing; Clinical; Clinical Medicine; Data; Diagnosis; Electroencephalography; Event; Frequencies; Goals; Human; Intravenous; Investigation; Lead; Light; Literature; Measurement; Measures; Medical; Memory; Memory Loss; Methodology; Methods; Monitor; Motivation; Operating Rooms; Operative Surgical Procedures; Outcome; Pain; Patients; Phase; Public Health; Publishing; Reaction; Records Controls; Relative (related person); Research; Sedation procedure; Short-Term Memory; Solutions; Stimulus; Systems Analysis; Techniques; Testing; Visual; brain electrical activity; design; experience; healthy volunteer; implicit memory; long term memory; memory recall; outcome forecast; prevent; public health relevance; sedative; sevoflurane; standard measure; tool

DESCRIPTION (provided by applicant): This project will study electrical brain-activity measures that may be able to indicate whether or not long-term memory is occurring, under light sedation. The goal is to develop a brain-monitor to be used in the operating room to ascertain if a patient's level of anesthesia has become too light, such that the patient can experience pain, and understand what is occurring in the operating room, and remember the experience. Such an event is rare, but traumatic. No present brain-analysis system accurately distinguishes the boundary in light anesthesia, between that level in which there will be explicit-memory and that level in which explicit-memory is missing. The fundamental scientific goal is to provide a tool for further investigations of the mechanisms of explicit memory, in animals as well as humans. If the goal were achieved, it would offer the chance to develop a clinical tool for analysis, diagnosis, or prognosis of medical conditions involving changes in memory (for which present tools are often inadequate). The project is health-related in that it addresses a problem in clinical medicine, and will provide a solution to that problem, if successful. PUBLIC HEALTH RELEVANCE: This project is relevant to public health because it studies humans and their reactions to sedation under anesthetic agents, to find a way to detect whether, in an operation, the patient is alert enough to remember experiences. This is a rare event in surgery, but should be prevented, if possible, with the techniques that will be developed in this research.

描述（由申请人提供）：该项目将研究脑电活动测量，这些测量可能能够表明在轻度镇静状态下是否出现长期记忆。目标是开发一种用于手术室的大脑监视器，以确定患者的麻醉水平是否太轻，以便患者能够感受到疼痛，了解手术室中发生的情况，并记住该经历。这种事件很少见，但却造成了创伤。目前还没有大脑分析系统能够准确区分浅麻醉的边界，即存在外显记忆的水平和缺失外显记忆的水平。基本的科学目标是为进一步研究动物和人类的外显记忆机制提供工具。如果这个目标实现了，它将提供开发一种临床工具的机会，用于分析、诊断或预测涉及记忆变化的医疗状况（目前的工具通常不足以解决这些问题）。该项目与健康相关，因为它解决了临床医学问题，如果成功，将为该问题提供解决方案。公共健康相关性：该项目与公共健康相关，因为它研究人类及其对麻醉剂镇静的反应，以找到一种方法来检测患者在手术中是否足够警觉以记住经历。这是手术中罕见的事件，但如果可能的话，应该通过本研究中开发的技术来预防。